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The Genetics of Age-Related Maculopathy

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Retinal Degeneration

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Abstract

Age-related maculopathy1(ARM) or age-related macular degeneration is the leading cause of irreversible vision loss in the elderly population in the United States and the Western world2–6 and a major public health issue. While ARM has been observed to have a genetic component, it has not been the subject of genetic investigations due to difficulties in diagnosis, late-onset, and complexity of expression. With the development of new genetic and analytical methods, it is now feasible to study ARM. The localization of the gene or genes that contribute to ARM susceptibility will guide studies of the underlying cause(s) of ARM. Identification of individuals who have an increased genetic susceptibility for developing ARM will provide the basis for future therapeutic and preventative interventions.

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Author information

Authors and Affiliations

  1. The Eye & Ear Institute of Pittsburgh, Ophthalmology Department, University of Pittsburgh, Pittsburgh, PA, 15213, USA

    Michael B. Gorin

  2. Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, 15213, USA

    Michael B. Gorin, Carmella Sarneso & Daniel E. Weeks

  3. Smith-Kettlewell Eye Research Institute, San Francisco, CA, 94115, USA

    T. Otis Paul & Julielani Ngo

Authors
  1. Michael B. Gorin
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  2. Carmella Sarneso
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  3. T. Otis Paul
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  4. Julielani Ngo
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  5. Daniel E. Weeks
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Editor information

Editors and Affiliations

  1. Cullen Eye Institute, Baylor College of Medicine, Houston, Texas, USA

    Joe G. Hollyfield  & Robert E. Anderson  & 

  2. Beckman Vision Center, University of California, San Francisco, San Francisco, California, USA

    Matthew M. LaVail

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© 1993 Springer Science+Business Media New York

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Gorin, M.B., Sarneso, C., Paul, T.O., Ngo, J., Weeks, D.E. (1993). The Genetics of Age-Related Maculopathy. In: Hollyfield, J.G., Anderson, R.E., LaVail, M.M. (eds) Retinal Degeneration. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2974-3_4

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  • DOI: https://doi.org/10.1007/978-1-4615-2974-3_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6294-4

  • Online ISBN: 978-1-4615-2974-3

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