Skip to main content
SpringerLink
Log in

Recent Developments in Genetic Epidemiology

  • Chapter
Human Population Genetics

  • 226 Accesses

Abstract

The foundations of genetic epidemiology were discussed several years ago (Morton, 1986), at a time when the field could easily be summarized (Morton, 1982;King et al., 1984). Recent publications have dealt with hearing impairment (Morton, 1991), cancer (Lynch and Tautu, 1991), coronary heart disease (Beam, 1992), and metabolic disease (Tikkanen and Tuomilehto, 1992). Many developments are reflected in the journal Genetic Epidemiology inaugurated in 1984, but most of the literature is in less specialized journals. A review of the past decade is overdue and will be attempted here.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Barbujani, G., Russo, A., Danieli, G.A., Spiegler, A.W.J., Borkowska, J., and Petrusewicz, I.H., 1990, Segregation analysis of 1885 DMD families: significant departure from the expected proportion of sporadic casesHum. Genet.84:522.

    Article  PubMed  CAS  Google Scholar 

  • Beam, A.G., 1992, “Genetics of Coronary Heart Disease”, Institute of Clinical Genetics, University of Oslo, Oslo.

    Google Scholar 

  • BEIR V, 1990, “Health Effects of Exposure to Low Levels of Ionizing Radiation”, National Academy Press, Washington D.C.

    Google Scholar 

  • Bittles, A.H., and Roberts, D.F., 1992, “Minority Populations. Genetics, Demography, and Health”, The Galion Institute, McMillan Press, London.

    Google Scholar 

  • Bonney, G.E., 1986, Regressive logistic models for familial disease and other binary traitsBiometrics42:611.

    Article  PubMed  CAS  Google Scholar 

  • Bundey, S., Alson, H., Kaur, A., Mi, S., and Lancashire, R., 1991, Why do UK-born Pakistani babies have high perinatal and neonatal mortality rates?Paed. Biomat. Epid.5:101.

    CAS  Google Scholar 

  • Chumakov, I., Rigault, P., Guillou, S., Ougen, P., Billaut, A., Guasconi, G., Gervy, P., Legall, I., Soularue, P., Grinas, L., Bougueleret, L., Bellannechantelot, C., Lacroix, B., Barillot, E., Gesnouin, P., Pook, S., Vaysseix, G., Frelat, G., Schmitz, A., Sambucy, J.L., Bosch, A., Estivill, X., Weissenback, J., Vignal, A., Riethman, H., Cox, D., Patterson, D., Gardiner, K., Hattori, M., Sakaki, Y., Ichikawa, H., Ohki, M., Lepaslier, D., Heilig, R., Antonarakis, S., and Cohen, D., 1992, Continuum of overlapping clones spanning the entire human chromosome 21q, Nature 359:380.

    Article  PubMed  CAS  Google Scholar 

  • Collins, and Morton, N.E., 1991, Significance of maximal lodsAnn. Hum. Genet.55:39.

    Article  PubMed  CAS  Google Scholar 

  • Dorman, J.S., 1992, Molecular epidemiology: applications of molecular biology to epidemiologic research (submitted).

    Google Scholar 

  • Falk, C.T., and Rubinstein, P., 1987, Haplotype relative risks: an easy way to construct a proper control sample for risk calculations, Ann. Hum. Genet. 51:227.

    Article  PubMed  CAS  Google Scholar 

  • Foote, S., Vollrath, D., Hilton, A., and Page, D.C., 1992, The human Y chromosome: overlapping DNA clones spanning the euchromatic region, Science 258:60.

    Article  PubMed  CAS  Google Scholar 

  • Haldane, J.B.S., 1919, The combination of linkage values, and the calculation of distance between loci of linked factors, J.Genet. 8:299.

    Article  Google Scholar 

  • Haldane, J.B.S., 1922, Sex ratio and unisexual sterility in hybrid animalsJ. Genet.12: 101.

    Article  Google Scholar 

  • Haldane, J.B.S., 1964, A defense of beanbag geneticsPerspect. Biol. Med.7:343.

    PubMed  CAS  Google Scholar 

  • Haldane, J.B.S., 1965, The implications of genetics for human society, in: “Genetics Today Proc. XI Int. Cong. Genet.” Geerts, S.J., ed., Pergamon Press, Oxford.

    Google Scholar 

  • Haldane, J.B.S., and Smith, C.A.B., 1947, A new estimate of the linkage between the genes for colour blindness and haemophilia in man, Ann. Eugen. 14:10.

    PubMed  CAS  Google Scholar 

  • Jordan, E., 1992, Invited Editorial: the Human Genome Project: where did it come from, where is it going?, Am. J. Hum. Genet. 51:1.

    PubMed  CAS  Google Scholar 

  • King, M.C., Lee, G.M., Spinner, N.B., Thomson, G., and Wrensch, M.R., 1984, Genetic epidemiology.Ann. Rev. Public Health5:1.

    Article  CAS  Google Scholar 

  • Lander, E.S., 1991, Invited editorial: Research on DNA catching up with courtroom applicationAm. J. Hum. Genet.48:819.

    PubMed  CAS  Google Scholar 

  • Lander, E.S., and Botstein, D., 1987, Homozygosity mapping: a way to map human recessive traits with the DNA of inbred childrenScience236:1567.

    Article  PubMed  CAS  Google Scholar 

  • Lander, E.S., Lincoln, S.E., 1988, The appropriate threshold for declaring linkage when allowing sex-specific recombination rates, Am. J. Hum. Genet., 43:396.

    PubMed  CAS  Google Scholar 

  • Lange, K., and Boehnke, M., 1992, Bayesian methods and optimal experimental design for gene mapping by radiation hybrids, Ann. Hum. Genet. 56:119.

    Article  PubMed  CAS  Google Scholar 

  • Lawrence, S., Keats, B.J., and Morton, N.E., 1992, The AD1 locus in familial Alzheimer diseaseAnn. Hum. Genet.56:295.

    Article  PubMed  CAS  Google Scholar 

  • Lawrence, S., Morton, N.E., and Cox, D.R., 1991, Radiation hybrid mapping.Proc. Nat. Acad. Sci. USA88:7477.

    Article  PubMed  CAS  Google Scholar 

  • Lerner, I.M., 1954, “Genetic Homeostasis”, John Wiley & Sons, New York.

    Google Scholar 

  • Lewontin, R.C., and Hartl, D.L., 1991, Population genetics in forensic DNA typingScience254:1745.

    Article  PubMed  CAS  Google Scholar 

  • Lynch, H.T., and Tautu, P., 1991, “Recent Progress in the Genetic Epidemiology of Cancer”, Spring-Verlag, Berlin.

    Book  Google Scholar 

  • Morton, N.E., 1961, Morbidity of children from consanguineous marriagesProgress in Medical Genetics1:261.

    Google Scholar 

  • Morton, N.E., 1982, Kinship and inbreeding in populations of Middle Pastern origin and controlsin“Current Developments in Anthropological Genetics”, Crawford, H., Mielke, J.H., eds., Plenum Press, New York, vol 2, pp. 449.

    Chapter  Google Scholar 

  • Morton, N.E., 1986, Foundations of genetic epidemiologyJ. Genet.65:202.

    Article  Google Scholar 

  • Morton, N.E. 1988, Multipoint mapping and the emperor’s clothesAnn. Hum. Genet.52:309.

    Article  PubMed  CAS  Google Scholar 

  • Morton, N.E., 1991, Genetic structure of forensic populationsProc. Natl. Acad. Sci. USA89:2556.

    Article  Google Scholar 

  • Morton, N.E., 1991, Genetic epidemiology of hearing impairment, in:“Genetics of Hearing Impairment”, Ruben, R.J., Van De Water, T.R., Steel, K.P. eds.Ann. N. Y. Acad. Sci.630:16.

    Google Scholar 

  • Morton, N.E., 1982, “Outline of Genetic Epidemiology” S. Karger, Basel.

    Google Scholar 

  • Morton, N.E., Collins, A., and Balazs, I., 1992, Bioassay of kinship for hypervariable loci in Blacks and CaucasiansProc. Natl. Acad. Sci. USA(in press).

    Google Scholar 

  • Morton, N.E., Collins, A., Lawrence, S., and Shields, D.C., 1992, Algorithms for a location databaseAnn. Hum. Genet.56:223.

    Article  PubMed  CAS  Google Scholar 

  • Morton, N.E., Crow, J.F., and Muller, H.J., 1956, An estimate of the mutational damage in man from data on consanguineous marriagesProc. Natl. Acad. Sci. USA.41:855.

    Article  Google Scholar 

  • Morton, N.E., and Lalouel, J.-M., 1979, Genetic counseling in sex linkageBirth Defects: Original Artic Series15 (5C):9.

    CAS  Google Scholar 

  • Morton, N.E., and Macpherson, J.N., 1992, Population genetics of the fragile-X syndrome: multiallelic model for the FMR1 locusProc. Nat. Acad. Sci. USA89:4215.

    Article  PubMed  CAS  Google Scholar 

  • Morton, N.E., Shields, D.C., and Collins, A., 1991, Genetic epidemiology of complex phenotypesAnn. Hum. Genet.55:301.

    Article  PubMed  CAS  Google Scholar 

  • Nee, J.V., Schull, W.J., McDonald, D.J., Morton, N.E., Kodani, M., Takeshima, K., Anderson, R.C., Wood, J., Brewer, R., Wright, S., Yamazaki, J., Suzuki, M., and Kitamura, S., 1953, The effect of exposure of parents to the atomic bombs on the first generation offspring in Hiroshima and Nagasaki: (preliminary report)Jap. J. Genet.28:211.

    Article  Google Scholar 

  • Neel, J.V., Schull, W.J., Awa, A.A., Satoh, C., Kato, H., Otake, M., and Yoshimoto, Y., 1990, The children of parents exposed to atomic bombs: estimates of the genetic doubling dose of radiation for humansAm. J. Hum. Genet.46:1053.

    PubMed  CAS  Google Scholar 

  • Nichols, R.A., and Balding, D.J., 1991, Effects of population structure on DNA fingerprint analysis in forensic scienceHeredity66:297.

    Article  PubMed  Google Scholar 

  • NRC Committee on DNA Technology in Forensic Science, 1992, “DNA Technology in Forensic Science”, National Academy Press, Washington DC.

    Google Scholar 

  • Paul, D.B., 1983, A war on two fronts: J.B.S. Haldane and the response to Lysenkoism in BritainJ. Hist. Biol.16:1.

    Article  PubMed  CAS  Google Scholar 

  • Penrose, L.S., 1935, The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified parentageAnn. Eugen.6:133.

    Google Scholar 

  • Rao, D.C., Morton, N.E., Lindsten, J., Hulten, M., and Yee, S., 1977, A mapping function for manHum. Hered.27:99.

    Article  PubMed  CAS  Google Scholar 

  • Sanghvi, L.D., 1966, Inbreeding in IndiaEugen. Quart.13:291.

    PubMed  CAS  Google Scholar 

  • Schull, W.J., Neel, J.V., and Hashizume, A., 1966, Some further observations on the sex ratio among infants born to survivors of the atomic bombings of Hiroshima and NagasakiAm. J. Hum. Genet.18:328.

    PubMed  CAS  Google Scholar 

  • Terwilliger, J.D., Dang, Y., and Ott, J., 1992, On the relative importance of marker heterozygosity and intermarker distance in gene mappingGenomics13:951.

    Article  PubMed  CAS  Google Scholar 

  • Tikkanen, M.J., and Perheentupa, J., (Eds) 1992, Special section in: “Molecular Genetics and Genetic Epidemiology of Cardiovascular Disease and Diabetes”Annals of Medicine24:313.

    Google Scholar 

  • Wald, A., 1947, “Sequential Analysis”, Wiley, New York.

    Google Scholar 

  • Williams, W.R., Thompson, M.W., and Morton, N.E., 1983, Complex segregation analysis and computer-assisted risk assessment for Duchenne muscular dystrophyAm. J. Med. Genet.14:315.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. CRC Genetic Epidemiology Research Group, The Princess Anne Hospital, Southampton, S09 4XY, UK

    Newton E. Morton

Authors
  1. Newton E. Morton
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Indian Statistical Institute, Calcutta, India

    Partha P. Majumder

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Morton, N.E. (1993). Recent Developments in Genetic Epidemiology. In: Majumder, P.P. (eds) Human Population Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2970-5_18

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2970-5_18

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6292-0

  • Online ISBN: 978-1-4615-2970-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation