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Recent Developments in the Theoretical Aspects of Linkage Analysis

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Human Population Genetics

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Abstract

The phenomenal pace of development of the genome project in recent years has been most beneficial to the field of linkage analysis. Many exciting theoretical and practical developments would not have been possible without the advances in molecular genetics. Presumably, the prospect that a complete human linkage map of approximately 2 cM resolution will soon be available will also have far reaching effects on society. In the not too distant future much of the genetic make-up of an individual may be recognized at birth. It is timely and demonstrates Haldane’s foresight that he envisioned this situation a long time ago. In an article entitled The future of biology written before 1927, he wrote of what are now called genetic markers and predicted that

“we could use them, by a method worked out on flies by Morgan of New York and his associates, as landmarks for the study of such characters as musical ability, obesity, and bad temper. When a baby arrived we should have a physical examination and a blood analysis done on him, and say something like this: ‘He has got— from his father, so it’s twenty to one that he will get the main gene that determined his father’s mathematical powers; but he’s got— from his mother— so it looks as if her father’s inability to keep away from alcohol would crop up in him again; you must look out for that.”

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Authors and Affiliations

  1. Department of Genetics and Development, Columbia University, Unit 58, 722 West 168th Street, New York, NY, 10032, USA

    Jurg Ott

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  1. Jurg Ott
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Editors and Affiliations

  1. Indian Statistical Institute, Calcutta, India

    Partha P. Majumder

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© 1993 Springer Science+Business Media New York

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Ott, J. (1993). Recent Developments in the Theoretical Aspects of Linkage Analysis. In: Majumder, P.P. (eds) Human Population Genetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2970-5_12

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  • DOI: https://doi.org/10.1007/978-1-4615-2970-5_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6292-0

  • Online ISBN: 978-1-4615-2970-5

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