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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 337))

Abstract

In 19322 Meldrum and Roughton in Cambridge and Stadie and Obrien in Philadelphia knew that there must be a catalytic acceleration of the dehydration of HCO3 - in the red cells in a lung capillary and were looking for an enzyme, which turned out to be carbonic anhydrase (CA). In contrast today we know there is CA in the carotid body, but we do not know its function. A fundamental assumption is that since nature carefully maintains CA in the carotid body, it is there for a definite purpose.Therefore I will briefly summarize our present knowledge about CA and list some possible ways in which it might be involved in chemosensing by the carotid body.

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References

  1. Buckler, K.J., R.D.Vaughan-Jones, C.Peers and P.C.G.Nye,Intracellular pH and its regulation in isolated type I carotid body cells of the neonatal rat, J.Physiol. (Lund). 436:107,1991.

    CAS  Google Scholar 

  2. Dodgson, S.J.,The carbonic anhydrases: overview of their importance in cellular physiology and in molecular genetics, in: “The carbonic anhydrases: cellular physiology and molocular genetics”, S.J.Dodgson, R.E.Tashian,G.Gros and N.D.Carter.eds., Plenum, New York, 1991.

    Chapter  Google Scholar 

  3. DuBois,A.B.,W.O.Fenn and A.G.Britt. CO2 dissociation curve of lung tissue.J. App. Physiol. 5:13 (1952).

    CAS  Google Scholar 

  4. Edsall,J.T, The carbonic anhydrases of erythrocytes, Harvey Lect., 62:191 (1968).

    Google Scholar 

  5. Forster, R.E.II,Methods for the measurement of carbonic anhydrase activity, in: “The carbonic anhydrases:cellular physiology and molocular genetics”, S.J.Dodgson, R.E.Tashian,G.Gros and N.D.Carter,eds., Plenum, New York, 1991.

    Google Scholar 

  6. Forster,R.E.,Buffering in blood with emphasis on Kinetics. In: “The kidney:physiology and pathophysiology”,2nd edition, D.W.Seldin and G.Giebisch,eds.,Raven,New York,to be published in 1992.

    Google Scholar 

  7. Geers,C., and G.Gros. Muscle carbonic anhydrascs:function in muscle contraction and in the homeostasis of muscle pH and pCO2, in: “The carbonic anhydrases:cellular physiology and molecular genetics”, S.J.Dodgson,R.E.Tashian,G.Gros and N.D.Carter,eds., Plenum, New York, 1991.

    Google Scholar 

  8. Gros,G., H.S.Rollema and R.E.Forster,The carbamate equilibrium of a-and e-amino groups of human hemoglobin at 37 °C.J.Biol.Chem. 256:5471 (1981).

    PubMed  CAS  Google Scholar 

  9. Hewett-Emmett,D.,and R.E.Tashian, Structure and evolutionary origins of the carbonic anhydrase multigene family, in: “The carbonic anhydrases:cellular physiology and molecular genetics”, S.J.Dodgson, R.E.Tashian,G.Gros and N.D.Carter.eds., Plenum, New York, 1991.

    Google Scholar 

  10. Khalifah,K.G., and D.N.Silverman. Carbonic anhydrase kinetics and molecular function, in: “The carbonic anhydrases:cellular physiology and molecular genetics”, S.J.Dodgson, R.E.Tashian,G.Gros and N.D.Carter.eds., Plenum, New York, 1991.

    Google Scholar 

  11. Lahiri,S., Carbonic anhydrase and chemoreception in carotid and aortic bodies, in: “The carbonic anhydrases: cellular physiology and molecular genetics”, S.J.Dodgson, R.E. Tashian, G. Gros and N.D.Carter.eds., Plenum, New York, 1991.

    Google Scholar 

  12. Longmuir,I.S., R.E.Forster and C.Woo. Diffusion of carbon dioxide through thin layers of solution. Nature 209:393 (1966).

    Article  CAS  Google Scholar 

  13. Maren,T.H.,Carbonic anhydrase: chemistry, physiology and inhibition, Physiol.Rev. 47:595,1967.

    PubMed  CAS  Google Scholar 

  14. Nioka,S.,R.P.Henry and R.E.Forster. Total CA activity in isolated perfused guinea pig lung by 18O-exchange method. J.Appl.Physiol. 65:2236 (1988).

    PubMed  CAS  Google Scholar 

  15. Pocker,Y., and S.Sarkanen.Carbonic anhydrase;structure, catalytic versatility and inhibition, Adv.Enzymol. 47:149 (1978).

    PubMed  CAS  Google Scholar 

  16. Quinn,J.A.,andT.L.Donaldson. Facilitated diffusion of CO2 and carbonic anhydrase activity, in:“ Biophysics and physiology of carbon dioxide”,C.Bauer, G.Gros and H.Bartelseds.,Springer, Berlin, 1980.

    Google Scholar 

  17. Sanyal,G.,E.R.Swenson,N.I.PessahandT.M.Maren. The carbon dioxide hydration activity of skeletal muscle carbonic anhydrase. Molecular Pharmac. 22:211(1982).

    CAS  Google Scholar 

  18. Simmonsson, I.,B-H Jonsson and S.Lindskog. A 13C nuclear magnetic resonance study of CO2–HCO3- exchange catalyzed by human carbonic anhydrase C at chemical equilibrium, Eur. J. Biochem. 93:409 (1979).

    Article  Google Scholar 

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© 1993 Springer Science+Business Media New York

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Forster, R.E. (1993). Carbonic Anhydrase and the Carotid Body. In: Data, P.G., Acker, H., Lahiri, S. (eds) Neurobiology and Cell Physiology of Chemoreception. Advances in Experimental Medicine and Biology, vol 337. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2966-8_20

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  • DOI: https://doi.org/10.1007/978-1-4615-2966-8_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6290-6

  • Online ISBN: 978-1-4615-2966-8

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