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Interactions between Tumor Necrosis Factor Alpha and Glucocorticoid Hormones in the Regulation of Tumor Cell Growth in Vitro

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Combination Therapies 2

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Abstract

Tumor necrosis factor-alfa (TNF-α) is a multifunctional cytokine with an important role in inflammation, tissue repair and immune reactions1,2,3 This molecule also exerts a cytocidal activity against some tumor cell lines but not against normal cells “in vitro”4. Several tumor cells are or become resistant, however, to the growth-inhibiting activity of TNF-α4,5,6 and the cytokine can also stimulate the growth of normal human fibroblasts as well as of some trasformed cells in culture7,8. Little is known about the mechanisms responsible for TNF-α mediated cytotoxicity9 and cytostatic, cytolytic and apoptotic4,10 effects have been reported in different cellular models.

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Authors and Affiliations

  1. Institutes of Clinica Medica I and Farmacologica Medica, Perugia University Medical School, 06100, Perugia, Italy

    Ildo Nicoletti, Graziella Migliorati & M. Cristina Pagliacci

  2. Perugia University Medical School, 06100, Perugia, Italy

    Fausto Grignani & Carlo Riccardi

Authors
  1. Ildo Nicoletti
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  2. Graziella Migliorati
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  3. M. Cristina Pagliacci
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  4. Fausto Grignani
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  5. Carlo Riccardi
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Editor information

Editors and Affiliations

  1. University of Rome “Tor Vergata”, Rome, Italy

    Enrico Garaci

  2. The Institute for Advanced Studies in Immunology and Aging, Washington, D.C., USA

    Allan L. Goldstein

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© 1993 Springer Science+Business Media New York

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Nicoletti, I., Migliorati, G., Pagliacci, M.C., Grignani, F., Riccardi, C. (1993). Interactions between Tumor Necrosis Factor Alpha and Glucocorticoid Hormones in the Regulation of Tumor Cell Growth in Vitro . In: Garaci, E., Goldstein, A.L. (eds) Combination Therapies 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2964-4_9

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  • DOI: https://doi.org/10.1007/978-1-4615-2964-4_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6289-0

  • Online ISBN: 978-1-4615-2964-4

  • eBook Packages: Springer Book Archive

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