Summary
IFNs are proteins produced by cells following stimulation with biological or synthetic inducers. The interaction with the membrane receptor is followed by the activation of the expression of particular genes that are responsible for their antiviral, antiproliferative and immunomodulatory properties. In this review we will briefly discuss the mechanisms exploited by IFNs to control at transcriptional level the expression of inducible genes. In particular we will focus on some characteristics of cis-acting DNA elements that are located upstream from the initiation site for RNA transcription and of nuclear transacting factors that are required for modulation of gene expression by IFNs.
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© 1993 Springer Science+Business Media New York
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Landolfo, S. et al. (1993). Regulation of Gene Expression by Interferons. In: Garaci, E., Goldstein, A.L. (eds) Combination Therapies 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2964-4_8
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DOI: https://doi.org/10.1007/978-1-4615-2964-4_8
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