Abstract
The effect of cocaine use/abuse on immune responses has recently received strong impulse from epidemiological data that have demonstrated a high prevalence of AIDS in poly-drug users1. In experimental models, administration of cocaine suppressed the antibody response to sheep red blood cells (SRBC)2, measured with plaque forming cells (PFC) assay, as well as Natural Killer (NK) cell activity and T lymphocyte-induced cytotoxycity3. In addition, in vivo cocaine administration suppresses the ability of spleen lymphocytes to produce Interferon (IFN)-γ, Interleukin (IL)-2 and IL-4, following in vitro stimulation by mitogens4. Phagocitic activity of peritoneal macrophages was inhibited by a single injection of cocaine, while short term administration induced a significant reduction of spleen and thymus weight2.
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© 1993 Springer Science+Business Media New York
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Ravagnan, G. et al. (1993). Effect of Thymosin α 1 on Cocaine-Induced Inhibition of T-Cell Dependent Murine Immune Response. In: Garaci, E., Goldstein, A.L. (eds) Combination Therapies 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2964-4_7
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DOI: https://doi.org/10.1007/978-1-4615-2964-4_7
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