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Thymosin α1 and α-Inteferon with Cisplatin and Etoposide in Advanced Non-Small-Cell Lung Cancer: A Phase II Study

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Combination Therapies 2

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Abstract

In recent years, biological response modifiers (BRMs) have emerged as an important new class of agents for treating cancer. Agents such as interferon (IFN) and interleukin 2 (IL-2) have been reported to induce significant tumor regression in various types of cancer usually resistant to chemotherapy (1,12), but their use in non-small-cell lung cancer (NSCLC) has received little attention.

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References

  1. E.T. Creagan, D.L. Ahmann, S.J. Green, H.J. Long, S. Frytak, J.R. O’Fallon and L.M. Itri, Phase II study of low-dose recombinant leukocyte a interferon in disseminated malignant melanoma, J. Clin. Oncol. 9: 1002 (1984).

    Google Scholar 

  2. W.K. Evans, D.W. Nixon, J.M. Daly, et al., A randomized study of oral nutritional support versus ad lib nutritional intake during chemotherapy for advanced colorectal and non-small-cell lung cancer, J. Clin. Oncol. 5: 113 (1987).

    PubMed  CAS  Google Scholar 

  3. C. Favalli, A. Mastino, T. Jezzi, S. Grelli, A.L. Goldstein, E. Garaci, Synergistic effect of thymosin a 1 and a -interferon on NK activity in tumor-bearing mice, Int. J. Immunopharmac. 11: 443 (1989).

    Article  CAS  Google Scholar 

  4. E. Garaci, A. Mastino, F. Pica, C. Favalli, Combination treatment using thymosin al and interferon after cyclophosphamide is able to cure Lewis lung carcinoma in mice, Cancer Immunol. Immunother. 32: 154 (1990).

    Article  PubMed  CAS  Google Scholar 

  5. D.C. Ihde, J.D. Minna, Non-small cell lung cancer Part II: Treatment, Curr. Probl. Cancer May/June (1991).

    Google Scholar 

  6. E.L. Kaplaplan, P. Meier, Nonparametric estimation from incomplete observations, J. Am. Stat. Assoc. 53: 457 (1958).

    Article  Google Scholar 

  7. J. Klastersky, J.P. Sculier, P. Rayez, P. Libert, J. Michel, G. Vandermoten, P. Rocmans, Y. Bonduelle, M. Mairesse, T. Michiels, J. Thiriaux, P. Mommen, O. Dalesio, A randomized study comparing a high and a standard dose of cisplatin in combination with etoposide in the treatment of advanced non-smallcell lung carcinoma, J. Clin. Oncol. 4: 1780 (1986).

    PubMed  CAS  Google Scholar 

  8. J. Klastersky, J.P. Sculier, G. Bureau, P. Libert, P. Rayez, G. Vandermoten, J. Thiriaux, J. Lecomte, R. Cordier, G. Dabouis, D. Brohee, L. Themelin, P. Mommen, Cisplatin versus cisplatin plus etoposide in the treatment of advanced non-small-cell lung cancer, J. Clin. Oncol. 7: 1087 (1989).

    PubMed  CAS  Google Scholar 

  9. K.D. Leichtling, S.A. Serrate and M.B. Sztein, Thymosin alpha 1 modulates the expression of high affinity interleukin-2 receptors on normal human lymphocytes, Int. J. Immunopharmac. 12: 19 (1990).

    Article  CAS  Google Scholar 

  10. E. Longeval and J. Klastersky, Combination chemotherapy with cisplatin and etoposide in bronchogenic squamous cell carcinoma and adenocarcinoma, Cancer 50: 2751 (1982).

    Article  PubMed  CAS  Google Scholar 

  11. A.B. Miller, B. Hoogstraten, M. Staquet, A. Winkler, Reporting results of cancer treatment, Cancer 47: 207 (1981).

    Article  PubMed  CAS  Google Scholar 

  12. S. Negrier, T. Philip, G. Stoter, S.D. Fossa, S. Janssen, A. lacone, F.S. Cleton, O. Eremin, L. Israel, C. Jasmin, C. Rugarli, H.V.D. Masse, N. Thatcher, M. Symann, H.H. Bartsch, L. Bergmann, J.T. Bijman, P.A. Palmer and C.R. Franks, Interleukin-2 with or without LAK cells in metastatic renal cell carcinoma: a report of a European Multicentre Study, Eur. J. Cancer Clin. Oncol. 25: S21 (1989).

    PubMed  Google Scholar 

  13. K.K. Oates and A.L. Goldstein, Thymosin, in: Biologic Therapy of Cancer, ed. V.T. De Vita, Jr. S. Hellman, S.A. Rosenberg, Publisher J.B. Lippincott Company, Philadelphia (1991).

    Google Scholar 

  14. S.A. Serrate, R.S. Schulof, L. Leonidaridis, A.L. Goldstein, M.B. Sztein, Modulation of human natural killer cell cytotoxic activity. Lymphokine production, and interleukin 2 receptor expression by thymic hormones, J. Immunol. 7: 2338 (1987).

    Google Scholar 

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Authors and Affiliations

  1. IstitutoRegina Elena, V.le Regina Elena, 291, 00161, Roma, Italy

    Massimo Lopez, Marina Della Giulia, Luigi Di Lauro & Patrizia Vici

  2. Istituto di Pneumologia, Università di Palermo, Via Trabucco, 180, 90146, Palermo, Italy

    Giovanni Bonsignore

  3. Centro Oncologico “G.Porfiri”, Ospedale S.M. Goretti, Via Canova, 04100, Latina, Italy

    Modesto D’Aprile

  4. Cattedra di Microbiologia, Università di Roma “Tor Vergata”, Via Orazio Raimondo, 8, 00173, Roma, Italy

    Cartesio Favalli & Enrico Garaci

Authors
  1. Massimo Lopez
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  2. Giovanni Bonsignore
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  3. Modesto D’Aprile
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  4. Cartesio Favalli
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  5. Marina Della Giulia
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  6. Luigi Di Lauro
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  7. Patrizia Vici
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  8. Enrico Garaci
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Editor information

Editors and Affiliations

  1. University of Rome “Tor Vergata”, Rome, Italy

    Enrico Garaci

  2. The Institute for Advanced Studies in Immunology and Aging, Washington, D.C., USA

    Allan L. Goldstein

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© 1993 Springer Science+Business Media New York

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Lopez, M. et al. (1993). Thymosin α1 and α-Inteferon with Cisplatin and Etoposide in Advanced Non-Small-Cell Lung Cancer: A Phase II Study. In: Garaci, E., Goldstein, A.L. (eds) Combination Therapies 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2964-4_17

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  • DOI: https://doi.org/10.1007/978-1-4615-2964-4_17

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6289-0

  • Online ISBN: 978-1-4615-2964-4

  • eBook Packages: Springer Book Archive

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