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Septic Shock Pathophysiology: Focus on Therapeutic Approach

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Abstract

Over the last 30 years, the prevalence of sepsis, and its sequelae, namely sepsis syndrome and septic shock has increased among hospitalized patients mostly due to improvements in medical care and technology.

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References

  1. Baumgartner JD, Glauser MP, McCutchan JA, et al. Prevention of Gram negative shock and death in surgical patients by antibody to endotoxin core glycolipid. Lancet, 1985; ii: 59–63.

    Article  Google Scholar 

  2. Beutler B, Krochin N, Milsark IW, et al. Control of cachectin (Tumor Necrosis Factors synthesis: mechanisms of endotoxin resi stance. Science, 1986; 232: 977–80.

    Article  PubMed  CAS  Google Scholar 

  3. Blick M, Sherwin SA, Rosenbaum M, et al. Phase-l study of recombinant Tumor Necrosis Factor in cancer patients. Cancer Res, 1987; 47: 2986–9.

    PubMed  CAS  Google Scholar 

  4. Bone RC. The pathogenesis of sepsis. Ann Intern Med, 1991; 115: 457–69.

    PubMed  CAS  Google Scholar 

  5. Bone RC, Fisher CJ Jr, Clemmer TP, et al. A controlled clinical trial of high-dose methylprednisolone in the treatment of severe sepsis and septic shock. N Engl J Med, 1987; 317: 653–58.

    Article  PubMed  CAS  Google Scholar 

  6. Bryan CS, Reynolds KL, Brenner ER. Analysis of 1,186 episodes of Gram-negative bacteremia in non-university hospitals: the effects of antimicrobial therapy. Rev Infect Dis, 1983; 5: 629–38.

    Article  PubMed  CAS  Google Scholar 

  7. Calandra T, Baumgartner JD, Gray GE, et al. Prognosis values of Tumor Necrosis Factor/cachectin, interleukin-1, alpha-interferon and gamma-interferon in the serum of patients with septic shock. J Infect Dis, 1990; 161: 982–87.

    Article  PubMed  CAS  Google Scholar 

  8. Cohen J. Clinical role of tumor necrosis factor in septic shock. Update Intensive Care Emergency Med, 1991; 14: 262–68.

    Article  Google Scholar 

  9. Dinarello CA, Mier JW. Lymphokines. N Engl J Med, 1987; 317: 940–45.

    Article  PubMed  CAS  Google Scholar 

  10. Durante W, Schini VB, Scott-Burden T, et al. Platelet inhibition by an L-arginine derived substance released by IL- ibeta-treated vascular smooth muscle cells. Am J Physiol, 1991; 261: H 2024–30.

    Google Scholar 

  11. Exley AR, Cohen J, Buurman WA et al. Monoclonal antibody to Tu mor Necrosis Factor in severe septic shock. Lancet, 1990; 335: 1275–77.

    Article  PubMed  CAS  Google Scholar 

  12. Faule KJ,Rossaint R, Keitel M et al. Successful treatment of severe adult respiratory distress syndrome with nitric oxide: the first three patients. Presented at Second International Meeting on the Biology of Nitric Oxide. London, october, 1991 ).

    Google Scholar 

  13. Galanos C, Freudenberg MA. Matsuura M. Mechanisms of the lethal action of endotoxin and endotoxin hypersensitivity. In: Friedman H, Klein TW, Nokano M, Nowotny A, eds. Endotoxin, advances in ex perimental medicine and biology. New York: Plenum Press, 1990; 603–19.

    Google Scholar 

  14. Ginsberg I. Mechanisms of cell and tissue injury induced by group A streptococci: relation to poststreptococcal sequelae. J Infect Dis, 1972; 126: 294–7.

    Article  Google Scholar 

  15. Glauser MP, Zanetti G, Baumgartner JD et al. Septic shock: pat hogenesis. Lancet, 1991; 338: 732–6.

    Article  PubMed  CAS  Google Scholar 

  16. Gorelick K, Scannon PJ, Hannigan J et al. Randomized placebo-controlled study of E5 monoclonal antiendotoxin antibody. In: Borrebaeck CA, Larrick JW, eds. Therapeutic monoclonal antibo dies. New York: Stockton Press, 1990: 253–61.

    Google Scholar 

  17. Granowitz EV, Santos AA, Poutsiaka DD et al. Production of IL-1-receptor antagonist during experimental endotoxaemia. Lancet, 1991; 338: 1423–4.

    Article  PubMed  CAS  Google Scholar 

  18. Guckian JC, Christensen WP, Fine DP. Evidence for quantitative variability of bacterial opsonic requirements. Infect Immun, 1978; 19: 882–5.

    Google Scholar 

  19. Hinshaw LB, Peduzzi P, Young E et al. Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med, 1987; 317: 659–65.

    Article  Google Scholar 

  20. Hutcheson IR, Whittle B Jr, Boughton-Smith NK. Role of nitric oxide in maintaining vascular integrity in endotoxin-induced in testinal damage in the rat. Br J Pharmacol, 1990; 101: 815–20.

    Article  PubMed  CAS  Google Scholar 

  21. Jacobs RF, Tabor DR. Immune cellular interactions during sepsis and septic injury. Crit Care Clin, 1989; 5: 9–26.

    PubMed  CAS  Google Scholar 

  22. Kreger BE, Craven DE, McCabe WR. Gram negative bacteriemia. IV Re-evaluation of clinical features and treatment in 612 patients. Am J Med, 1980; 68: 344–55.

    Article  PubMed  CAS  Google Scholar 

  23. Kuhweide R, Van Damme J, Ceuppens JL. Tumor necrosis factor-alpha and interleukin 6 synergistically induce T cell growth. Eur J lmmunol, 1990; 20: 1019–25.

    Article  CAS  Google Scholar 

  24. Li TC, Phillips MC, Shaw L et al. On-site physician staffing in a community hospital intensive care unit. Impact on test and pro cedure use and on patient outcome. JAMA, 1984; 252: 2023–7.

    Article  PubMed  CAS  Google Scholar 

  25. McCabe WR, DeMaria A Jr, Berberich H et al. Immunization with rough mutants of Salmonella minnesota: protective activity of IgM and IgG antibody to the R595 (Re chemotype) mutant. J Infect Dis, 1988; 158: 29–30.

    Article  Google Scholar 

  26. Michie MR, Manogue KR, Springs DR et al.Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med, 1988; 318: 1481–6.

    Article  PubMed  CAS  Google Scholar 

  27. MMWR. Increase in national hospital discharge rates for septicemia. United States, 1979–1987, MMWR, 39: 31–4.

    Google Scholar 

  28. Nathanson C, Danner RL, Reilly JM et al. Antibiotics versus car diovascular support in a canine model of human septic shock. Am J Physiol, 1990; 259 (5pt2) H 1440–7.

    Google Scholar 

  29. Nathan CF, Hibbs JB. Role of nitric oxide synthesis in macrophage antimicrobial activity. Cuir Opin Immunol, 1991; 3: 65–70.

    Article  CAS  Google Scholar 

  30. Nva E, Palmer RMJ, Moncada S. Inhibition of nitric oxide synthesis in septic shock: how much is beneficial? Lancet, 1991; 338: 1555–57.

    Article  Google Scholar 

  31. Palmer RMJ, Ferrige AG, Moncada S. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature, 1987; 327::524–26.

    Article  PubMed  CAS  Google Scholar 

  32. Parker MM, Parrillo JE. Septic shock: hemodynamics and pathoge nesis. JAMA, 1983; 250: 3324–7.

    Article  PubMed  CAS  Google Scholar 

  33. Parrillo JE. Management of septic shock: present and future. Ann Intern Med, 1991; 115: 491–93.

    PubMed  CAS  Google Scholar 

  34. Parrillo JE, Parker MM, Natanson C et al. NIH Conference. Septic shock in humans: advances in the understanding of pathogenesis, cardiovascular dysfunction and therapy. Ann Intern Med, 1990; 113: 227–42.

    PubMed  CAS  Google Scholar 

  35. Petros A, Bennett D, Valiance P. Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock. Lancet, 1991; 338: 1557–58.

    Article  PubMed  CAS  Google Scholar 

  36. Reynolds HN, Haupt MT, Thill-Baharozian MC et al. Impact of critical care physician staffing on patients with septic shock in a university hospital medical intensive care unit. JAMA, 1988; 260: 3446–50.

    Article  PubMed  CAS  Google Scholar 

  37. Rothberger H, Zimmerman TS, Spiegelberg HL et al. Leukocyte procoagulant activity: enhancement of production in vitro by IgG and antigen-antibody complexes. J Clin Invest, 1977; 59: 549–61.

    Article  PubMed  CAS  Google Scholar 

  38. Silva AT, Bayston KF, Cohen J. Prophylactic and therapeutic of fects of a monoclonal antibody to tumor necrosis factor-alpha in experimental Gram-negative shock. J Infect Dis, 1990; 162: 421–27.

    Article  PubMed  CAS  Google Scholar 

  39. Sprung CL, Caralis PV, Marcia’ E et al. The effect of high-dose corticosteroids in patients with septic shock. A prospective, controlled study. N Engl J Med, 1984; 311; 1137–43.

    Article  PubMed  CAS  Google Scholar 

  40. Ziegler EJ, Fisher CJ, Sprung CL et al. Treatment of Gram nega tive bacteremia and septic shock with HA-1A human monoclonal an tibody against endotoxin. N Engl J Med, 1991; 324: 429–36.

    Article  PubMed  CAS  Google Scholar 

  41. Ziegler Ej, McCutchan JA, Fierer J et al. Treatment of Gram ne gative bacteremia and shock with human antiserum to a mutant E scherichia coli. N Engl J Med, 1932; 307: 1225–30.

    Google Scholar 

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Palmieri, G., Nicoletti, G., Cantoni, S., Bucci, L. (1993). Septic Shock Pathophysiology: Focus on Therapeutic Approach. In: Garaci, E., Goldstein, A.L. (eds) Combination Therapies 2. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2964-4_12

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  • DOI: https://doi.org/10.1007/978-1-4615-2964-4_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6289-0

  • Online ISBN: 978-1-4615-2964-4

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