Abstract
The experimental application of the quantitative theory of metabolic regulation1,2 allowed to demonstrate that the control of mitochondrial respiration is not concentrated at one step and various processes prevail in control at different metabolic states3–5. The problem was investigated mainly on mitochondria oxidizing succinate. This metabolite is generated within mitochondria during oxidation of other substrates, so it can be considered as substrate for mitochondria only with some reservations6. At the same time the question arises as to the distribution of control in the case of oxidation of pyruvate and fatty acids, which are the main fuel for mitochondrial respiration in the heart.
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© 1993 Springer Science+Business Media New York
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Mildažienė, V. et al. (1993). Control of Respiration in Heart Mitochondria: Comparative Study of Oxidation of Succinate and NAD-Dependent Substrates. In: Schuster, S., Rigoulet, M., Ouhabi, R., Mazat, JP. (eds) Modern Trends in Biothermokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2962-0_54
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DOI: https://doi.org/10.1007/978-1-4615-2962-0_54
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