Abstract
Metabolic control analysis (for review see Ref. 1) allows insight in the control properties of complicated enzymatic pathways. It also attempts to clarify the regulatory processes that keep these pathways at their desired operation point2,3. It is based on the concept that enzymes show elasticity for the various metabolites in a pathway, or, from another point of view, that metabolites show regulability for the various enzymes, which is expressed in terms of elasticity coefficients. Elasticity is inversely related with the enzymatic control of maintaining the steady state as well as of keeping the concentration of the metabolites constant. The result of this internal control is that any intrusion into either steady state or metabolite concentration is nullified, so, that the uniqueness of steady states is conserved.
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© 1993 Springer Science+Business Media New York
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van der Gugten, A.A., Westerhoff, H.V. (1993). Internal Regulation. The C·E = I = E·C Square-Matrix Method Illustrated for a Simple Case of a Complex Pathway. In: Schuster, S., Rigoulet, M., Ouhabi, R., Mazat, JP. (eds) Modern Trends in Biothermokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2962-0_40
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DOI: https://doi.org/10.1007/978-1-4615-2962-0_40
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