Abstract
Regulation of gene expression is a process of central importance in cellular metabolism but also in disease, in development of differentiated organisms, in immunology, and many other life functions. Gene expression regulation is also paramount in the founding and still important process in the biotechnology industry, namely manufacture of a valuable protein based on overexpression of the corresponding cloned gene. The ideal qualitative profile of a typical batch process for producing such a protein involves an initial growth phase in which the cell density of recombinant cells is increased, followed by a production phase in which the desired protein is accumulated.
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© 1993 Springer Science+Business Media New York
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Chen, W., Lee, SB., Kallio, P., Bailey, J.E. (1993). Invention of a Useful Transcriptional Regulation System Using Mechanistic Mathematic Modeling. In: Schuster, S., Rigoulet, M., Ouhabi, R., Mazat, JP. (eds) Modern Trends in Biothermokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2962-0_25
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DOI: https://doi.org/10.1007/978-1-4615-2962-0_25
Publisher Name: Springer, Boston, MA
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