Abstract
The pyruvate dehydrogenase complex (PDC) is one of the most intensively studied multienzyme complexes. The PDC plays a central role in intermediary metabolism, being a major site of regulation1. We construct a simple kinetic model, predicting the so-called ‘critical’ regulation2 for mammalian PDC. The regulation of the critical type is characteristic of bistable systems having two alternative stable steady states2 and may be observed as a steep change in metabolite levels.
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References
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© 1993 Springer Science+Business Media New York
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Goldstein, B.N., Selivanov, V.A. (1993). Critical Regulation of Multienzyme Complexes: A Kinetic Model for the Mammalian Pyruvate Dehydrogenase Complex. In: Schuster, S., Rigoulet, M., Ouhabi, R., Mazat, JP. (eds) Modern Trends in Biothermokinetics. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2962-0_16
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DOI: https://doi.org/10.1007/978-1-4615-2962-0_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6288-3
Online ISBN: 978-1-4615-2962-0
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