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Nicotinic Cholinergic Regulation of Tetrahydrobiopterin Levels in Bovine Adrenal Chromaffin Cells

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Book cover Chemistry and Biology of Pteridines and Folates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 338))

Abstract

Catecholamines (CA) in adrenergic neurons are maintained at a relatively constant level despite wide variations in neural activity1. The mechanism of this regulation is the modulation of the conversion of tyrosine to dopa, the rate limiting step in CA biosynthesis. The enzyme catalyzing this step, tyrosine hydroxylase2 (TH; EC 1.14.16.2; 1-tyrosine, tetrahydropteridine:oxygen oxidoreductase, 3-hydroxylating), is subject to a variety of regulatory mechanisms. Acutely, TH is regulated by negative feedback inhibition of TH by intracellular CA3 and activation through phosphorylation of TH by four second messenger-activated protein kinases4. At the chronic level the quantity of TH is regulated through trans-synaptic mediated increase in the synthesis of enzyme molecules5.

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Author information

Authors and Affiliations

  1. Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, TX, 77030, USA

    Jack C. Waymire

  2. Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, 36688, USA

    June E. Ayling

  3. Department of Pharmacology, University of Nevada School of Medicine, Reno, NV, 89509, USA

    Gale L. Craviso

Authors
  1. Jack C. Waymire
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  2. June E. Ayling
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  3. Gale L. Craviso
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Editor information

Editors and Affiliations

  1. Dept of Pharmacology College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    June E. Ayling

  2. Dept. of Biochemistry College of Medicine, University of South Alabama, Mobile, AL, 36688, USA

    M. Gopal Nair

  3. College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    Charles M. Baugh

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© 1993 Springer Science+Business Media New York

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Waymire, J.C., Ayling, J.E., Craviso, G.L. (1993). Nicotinic Cholinergic Regulation of Tetrahydrobiopterin Levels in Bovine Adrenal Chromaffin Cells. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_47

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  • DOI: https://doi.org/10.1007/978-1-4615-2960-6_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6287-6

  • Online ISBN: 978-1-4615-2960-6

  • eBook Packages: Springer Book Archive

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