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Co-Induction of Tetrahydrobiopterin (BH4) Levels and Tyrosine Hydroxylase Activity in Cultured PC12 Cells

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Book cover Chemistry and Biology of Pteridines and Folates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 338))

Abstract

BH4 is the cofactor for Phenylalanine hydroxylase, as well as tyrosine and tryptophan hydroxylases, which are the rate-limiting enzymes in catecholamine (CA) and Serotonin synthesis, respectively. CTP cyclohydrolase (CTP-CH) and sepiapterin reductase (SR) catalyze the initial and final steps in BH4 biosynthesis, respectively. Because no intermediates are detected, CTP-CH is thought to be the rate-limiting enzyme in nonprimate BH4 biosynthesis. In humans, the existence of neopterin in fluids suggests that other enzymes following CTP-CH may also play a regulatory role in BH4 biosynthesis.

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References

  1. Abou-Donia, M.M., Wilson, S.P., Zimmerman, T.P., Nichol,C.A., and Viveros, O.H.: J. Neurochem., 46: 1190–1199, 1986.

    Article  PubMed  CAS  Google Scholar 

  2. Baruchin, A., Weisberg, E.P., Miner, L.L., Ennis, D,Nisenbaum, L.K., Naylor, E., Stricker, E.M., Zigmond,M.J., and Kaplan, B.B.: J. Neurochem., 54: 1769–1775, 1990.

    Article  PubMed  CAS  Google Scholar 

  3. Greene LA and Tischler A.S.: Proc. Natl. Acad. Sci. USA,73: 2424–2428,1976.

    Article  PubMed  CAS  Google Scholar 

  4. Brautigam, M., Dreesen, R., and Herken, H.:Journal on Neurochemistry, 42: 390–396,1984.

    Article  CAS  Google Scholar 

  5. Wessels-Reiker, M., Haycock, J.W., Howlett, A.C., andStrong, R.: The Journal of Biological Chemistry, 266: 9347–9350,1991.

    PubMed  CAS  Google Scholar 

  6. Suzuki H, Nakanishi N, YamadaS: Biochem. Biophys. Res.Comm., 153: 382–387, 1988.

    Article  PubMed  CAS  Google Scholar 

  7. Levine, R.A., Pollard, H.B., and Kuhn, D.M.: Anal.Biochem., 143: 205–208,1984.

    Article  PubMed  CAS  Google Scholar 

  8. Blau, N. and Niederwieser, A.: Anal. Biochem. 128:446–452,1982.

    Article  Google Scholar 

  9. Levine, RA, Zoephel, G.P., Niederwieser, A., andCurtius, H.C.: J. Pharmacol. Exp. Ther., 242: 514–522, 1987.

    PubMed  CAS  Google Scholar 

  10. Levine, RA, Kapatos, G., Kaufman, S., andMilstien, S.: J. Neurochem., 54:1218–1224,1990.

    Article  PubMed  CAS  Google Scholar 

  11. Bradford M.M.: Analyt. Biochem. 72, 248–254,1976.

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. William T. Gossett Neurology Labs, Henry Ford Hospital, Detroit, MI, USA

    Panagiotis Z. Anastasiadis & Robert A. Levine

  2. Cellular and Clinical Neurobiology Program, Department of Psychiatry, Wayne State University, Detroit, MI, USA

    Panagiotis Z. Anastasiadis, Donald M. Kuhn & Robert A. Levine

  3. Center for Molecular Biology, Wayne State University, USA

    J. Christopher States

  4. Veterans Administration Medical Center, Allen Park, MI, USA

    Robert A. Levine

Authors
  1. Panagiotis Z. Anastasiadis
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  2. J. Christopher States
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  3. Donald M. Kuhn
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  4. Robert A. Levine
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Editor information

Editors and Affiliations

  1. Dept of Pharmacology College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    June E. Ayling

  2. Dept. of Biochemistry College of Medicine, University of South Alabama, Mobile, AL, 36688, USA

    M. Gopal Nair

  3. College of Medicine, Universily of South Alabama, Mobile, AL, 36688, USA

    Charles M. Baugh

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© 1993 Springer Science+Business Media New York

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Anastasiadis, P.Z., States, J.C., Kuhn, D.M., Levine, R.A. (1993). Co-Induction of Tetrahydrobiopterin (BH4) Levels and Tyrosine Hydroxylase Activity in Cultured PC12 Cells. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_45

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  • DOI: https://doi.org/10.1007/978-1-4615-2960-6_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6287-6

  • Online ISBN: 978-1-4615-2960-6

  • eBook Packages: Springer Book Archive

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