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Properties and Reactions of Pteridines Carrying Functionalised Side Chains at the 3-Position

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Chemistry and Biology of Pteridines and Folates

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 338))

Abstract

It is already known that some pteridines can act as photosensitisers,1 and it has been observed recently2 that ultraviolet irradiation of DNA in presence of a pteridine can cause widespread but random cleavage of the DNA chain. The chemistry described here arose out of a requirement to attach a pteridine to a synthetic oligonucleotide for purposes of inducing a photochemical lesion on a DNA chain at a specific targeted position. This paper reports on some new compounds, reactions, and ring systems, which were investigated during the preparation of a pteridine with a functionalised side chain at position 3. This pteridine was successfully attached to the 5’-OH of a synthetic oligonucleotide.

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References

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© 1993 Springer Science+Business Media New York

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Boyle, P., Camier, R. (1993). Properties and Reactions of Pteridines Carrying Functionalised Side Chains at the 3-Position. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_2

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  • DOI: https://doi.org/10.1007/978-1-4615-2960-6_2

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6287-6

  • Online ISBN: 978-1-4615-2960-6

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