Abstract
It is already known that some pteridines can act as photosensitisers,1 and it has been observed recently2 that ultraviolet irradiation of DNA in presence of a pteridine can cause widespread but random cleavage of the DNA chain. The chemistry described here arose out of a requirement to attach a pteridine to a synthetic oligonucleotide for purposes of inducing a photochemical lesion on a DNA chain at a specific targeted position. This paper reports on some new compounds, reactions, and ring systems, which were investigated during the preparation of a pteridine with a functionalised side chain at position 3. This pteridine was successfully attached to the 5’-OH of a synthetic oligonucleotide.
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The DNA synthesiser experiment was carried out by Dr. R.J.H. Davies and Mr. C. Stevenson, in the biochemical laboratories of Queen’s University, Belfast.
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© 1993 Springer Science+Business Media New York
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Boyle, P., Camier, R. (1993). Properties and Reactions of Pteridines Carrying Functionalised Side Chains at the 3-Position. In: Ayling, J.E., Nair, M.G., Baugh, C.M. (eds) Chemistry and Biology of Pteridines and Folates. Advances in Experimental Medicine and Biology, vol 338. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2960-6_2
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DOI: https://doi.org/10.1007/978-1-4615-2960-6_2
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6287-6
Online ISBN: 978-1-4615-2960-6
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