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The Chemokines pp 65–75Cite as

L-Arginine/Nitric Oxide Pathway: A Possible Signal Transduction Mechanism for the Regulation of the Chemokine IL-8 in Human Mesangial Cells

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 351))

Abstract

The central function of the mesangial cell within the kidney is the control of glomerular filtration rate primarily via the regulation of mesangial cell tone. A secondary function of this specialised pericyte is to maintain the integrity of the glomerulus via matrix synthesis and provide support for the capillary loops. The elicitation of neutrophils and monocytes from the circulation into the inflamed glomerulus accompanied by proliferation of resident mesangial cells and expansion of mesangial matrix are prominent features of immunologically mediated glomerulonephritis (1).

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Bath, Claverton Down, Bath, UK

    Zarin Brown, Rachel L. Robson & John Westwick

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  1. Zarin Brown
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  2. Rachel L. Robson
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  3. John Westwick
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Editor information

Editors and Affiliations

  1. Sandoz Research Institute, Vienna, Austria

    I. J. D. Lindley

  2. University of Bath, Bath, UK

    J. Westwick

  3. University of Michigan, Ann Arbor, Michigan, USA

    S. Kunkel

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© 1993 Springer Science+Business Media New York

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Brown, Z., Robson, R.L., Westwick, J. (1993). L-Arginine/Nitric Oxide Pathway: A Possible Signal Transduction Mechanism for the Regulation of the Chemokine IL-8 in Human Mesangial Cells. In: Lindley, I.J.D., Westwick, J., Kunkel, S. (eds) The Chemokines. Advances in Experimental Medicine and Biology, vol 351. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2952-1_8

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  • DOI: https://doi.org/10.1007/978-1-4615-2952-1_8

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6283-8

  • Online ISBN: 978-1-4615-2952-1

  • eBook Packages: Springer Book Archive

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