Abstract
The identification of tumor-derived chemotactic factors (TDCF) specific for monocytes (1) is one of the pathways that led to the identification of MCP-1 (2-6). Macrophages are a major component of the lymphoreticular infiltrate of rodent and human tumors (7). Since these cells are situated at the very interface between tumor and host, they may represent a strategically located target for therapeutic intervention. Interest in these cells is stimulated by the knowledge that macrophages have the potential to kill neoplastic cells including drug-resistant variants surviving conventional chemotherapy. Tumor-associated macrophages (TAM) derive from circulating monocytic precursors. The functional properties of macrophages infiltrating murine and human metastatic tumors have been characterized in an effort to obtain indications as to the role played by these cells in the immunobiology of neoplastic tissues (7). This analysis has indicated how TAM can contribute to important aspects of tumor tissue biology, such as fibrin deposition and angiogenesis.
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Mantovani, A. et al. (1993). Monocyte Chemotactic Protein-1 (MCP-1): Signal Transduction and Involvement in the Regulation of Macrophage Traffic in Normal and Neoplastic Tissues. In: Lindley, I.J.D., Westwick, J., Kunkel, S. (eds) The Chemokines. Advances in Experimental Medicine and Biology, vol 351. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2952-1_6
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DOI: https://doi.org/10.1007/978-1-4615-2952-1_6
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