Abstract
An important initiating event in atherogenesis is the entry of monocytes into the vessel wall. In cholesterol fed animals after approximately one week of feeding, monocytes begin to bind to the vessel wall and migrate into the subendothelial space (1,2). Here they take up lipid and form foam cells. Monocyte binding occurs only in certain areas of the vessel referred to as areas of prediliction (3). In these areas liproteins accumulate (4), and several investigators have shown that these lipoproteins are oxidized (5,6). Our group has studied the effects of minimally oxidized LDL (MM-LDL) on the interactions of monocytes with endothelial cells (7,8).
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© 1993 Springer Science+Business Media New York
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Berliner, J.A. et al. (1993). Induction of Chemotactic Cytokines by Minimally Oxidized Ldl. In: Lindley, I.J.D., Westwick, J., Kunkel, S. (eds) The Chemokines. Advances in Experimental Medicine and Biology, vol 351. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2952-1_2
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DOI: https://doi.org/10.1007/978-1-4615-2952-1_2
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