Skip to main content
SpringerLink
Log in

Molecular Mechanism of Interleukin-8 Gene Expression

  • Chapter
The Chemokines

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 351))

Abstract

Leukocyte infiltration into the lesion is a hallmark of inflammatory reactions to tissue injuries caused by various conditions including trauma, invasion of foreign particles, ischemia-reperfusion syndrome, malignant diseases, and autoimmune diseases. The types of infiltrating leukocytes depend on the kind, degree, and timing of tissue injuries. Although several leukocyte chemotactic factors including C5a, leukotriene B4 have long been identified, these factors have chemotactic activities for any kind of leukocytes, suggesting the existence of cell type-specific leukocyte chemotactic factors.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Oppenheim, J.J., C.O.C. Zachariae, N. Mukaida, and K. Matsushima. 1991. Properties of the novel inflammatory supergene “intercrine” cytokine family. Ann.Rev.Immunol.9: 617–648.

    Article  CAS  Google Scholar 

  2. Yoshimura, T., K. Matsushima, J.J. Oppenheim, and E.J. Leonard. 1987. Purification of a human monocyte-derived neutrophil chemotactic factor that shares sequence homology with other host defense cytokines. Proc.NatlAcad.Sci.U.S.A.84: 9233–9237.

    Article  CAS  Google Scholar 

  3. Larsen, C.G., A.O. Andersen, E. Appella, J.J. Oppenheim, and K. Matsushima. 1989. Neutrophil activating protein (NAP-1) is also chemotactic for T lymphocytes.Science243: 1464–1466.

    Article  PubMed  CAS  Google Scholar 

  4. White, M.V., T. Yoshimura, W. Hook, M. Kaliner, and E.J. Leonard. 1989. Neutrophil attractant/activation protein (NAP-1) causes human basophil histamine release. Immunol.Lett.22: 151–154.

    Article  PubMed  CAS  Google Scholar 

  5. Huber, A.R., S.L. Kunkel, R.F. Todd, and S.J. Weiss. 1991. Transendothelial neutrophil migration by endogenous interleukin-8. Science254: 99–102.

    Article  PubMed  CAS  Google Scholar 

  6. Mukaida, N., A. Hishinuma, C.O.C. Zachariae, JJ. Oppenheim, and K. Matsushima. 1992. Regulation of the human interleukin 8 gene expression and binding of several other members of the intercrine family to receptors for IL 8. In Chemotactic Cytokines, Advances in experimental medicine and biology, Vol. 305. (Westwick, J., S. Kunkel, and IJ.D. Lindley, eds.) Plenum Press, New York (in press).

    Google Scholar 

  7. Sugano, S., M.Y. Soeckle, and H. Hanafusa. 1987. Transformation by Rous sarcoma virus induces a novel gene with homology to amitogenic platelet protein. Cell49: 321–328.

    Article  PubMed  CAS  Google Scholar 

  8. Sica A., K. Matsushima, J.M. Wang, E. Polentarutti, E. Dejana, F. Colotta, and A. Mantovani. 1990. IL-1 transcriptionally activates the neutrophil chemotactic factor/IL-8 gene in endothelial cell. Immunol. 69: 548–553.

    CAS  Google Scholar 

  9. Mukaida, N., G.L. Gusella, T. Kasahara, Y. Ko, C.O.C. Zachariae, T. Kawai, and K. Matsushima. 1992. Molecular analysis of the inhibition of interleukin-8 production by dexamethasone in a human fibrosarcoma cell line. Immunology75: 674–679.

    PubMed  CAS  Google Scholar 

  10. Kasahara, T., N. Mukaida, K. Yamashita, H. Yagisawa, T. Akahoshi, and K. Matsushima. 1991. IL-1 and TNF-a induction of IL-8 and monocyte chemotactic and activating factor (MCAF) mRNA expression in a human astrocytoma cell line. Immunology74: 60–67.

    PubMed  CAS  Google Scholar 

  11. Mukaida, N., M. Shiroo, and K. Matsushima. 1989. Genomic structure of the human monocyte-derived neutrophil chemotactic factor (MDNCF)/interleukin 8. J.Immunol.143: 1366–1371.

    PubMed  CAS  Google Scholar 

  12. Yasukawa, K., T. Hirano, Y. Watanabe, K. Muratani, T. Matsuda, S. Nakai, and T. Kishimoto. 1987. Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene. EMBO J. 6: 2939–2945.

    PubMed  CAS  Google Scholar 

  13. Mukaida, N., M. Yann, and K. Matsushima. 1990. Cooperative interaction of nuclear factor kB and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J.Biol.Chem.265: 21128–21133.

    PubMed  CAS  Google Scholar 

  14. Mahe, Y., N. Mukaida, K. Kuno, M. Akiyama, N. Ikeda, K. Matsushima, and S. Murakami. 1991. Hepatitis B virus X protein transactivates human interleukin-8 gene through acting on nuclear factor kB and CCAAT/enhancer-binding protein-like cis-elements. J.Biol.Chem.266: 13759–13763.

    PubMed  CAS  Google Scholar 

  15. Schmitz, M.L., T. Henkel, and P.A. Baeuerle. 1991. Proteins controlling the nuclear uptake of NF-kB, rel and dorsal. Trends Cell Biol. 1: 130–137.

    Article  PubMed  CAS  Google Scholar 

  16. Ghosh, S. and D. Baltimore. 1990. Activation in vitro of NF-kB by phosphorylation of its inhibitor IkB. Nature344: 678–682.

    Article  PubMed  CAS  Google Scholar 

  17. Shiroo, M. and K. Matsushima. 1989. Enhanced phosphorylation of 65 and 75 kDa proteins by tumor necrosis factor and interleukin-1 in human peripheral blood mononuclear cells. Cytokine2: 13–20.

    Article  Google Scholar 

  18. Wu, J.Y., Z.-Y. Zhou, A. Judd, C.A. Cartwright, and W.S. Robinson. 1990. The hepatitis B virus-encoded transcriptional trans-activator hbx appears to be a novel protein serine/threonin kinase. Cell63: 687–695.

    Article  PubMed  CAS  Google Scholar 

  19. Leclair, K. P., M.A. Blanar, and P.A. Sharp. 1992. The p50 subunit of NF-kB associates with the NF-1L6 transcription factor. ProcNatlAcad.Sci.U.S.A. (in press).

    Google Scholar 

  20. Nakamura, H., K. Yoshimura, H.A. Jaffe, and R.G. Crystal. 1991. Interleukin-8 gene expression in human bronchial epithelial cells. J.Biol.Chem.266: 19611–19617.

    PubMed  CAS  Google Scholar 

  21. Yasumoto, K., S. Okamoto, N. Mukaida, S. Murakami, M. Mai, and K. Matsushima. 1992. Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB like binding site of the interleukin 8 gene. J.Biol.Chem. (in press).

    Google Scholar 

  22. Kawakami, K., C. Scheidereit, and R.G. Roeder. 1988. Identification and purification of a human immunoglobulin-enhancer-binding protein (NF-kB) that activates transcription from a human immunodeficiency virus type 1 promoter in vitro. Proc.Natl.Acad.Sci.U.S.A.85: 4700–4704.

    Article  PubMed  CAS  Google Scholar 

  23. Minamoto, T., M. Mai, K. Watanabe, A. Ooi, T. Kitamura, Y. Takahashi, H. Ueda, T. Ogino, and I. Nakanishi. 1990. Medullary carcinoma with lymphocytic infiltration of the stomach. Cancer66: 945–952.

    Article  PubMed  CAS  Google Scholar 

  24. Aggarwal, B.A., T.E. Eessalu, and P.E. Hass. 1985. Characterization of receptors for human tumor necrosis factor and their regulation by gamma-interferon. Nature318: 665–667.

    Article  PubMed  CAS  Google Scholar 

  25. Johnson, D.R. and J.S. Pober. 1990. Tumor necrosis factor and immune interferon synergistically increase transcription of FILA class I heavy-and light-chain genes in vascular endothelium. Proc. NAt. Acad. Sci. U.SA.87: 5183–5187.

    Article  CAS  Google Scholar 

  26. Frieberg, L., T. Kjellstrom, and G.F. Nordberg. 1986. Chapter 7. Cadmium. In Handbook on the Toxicology of Metals, 2nd ed., (Friberg, L., Nordberg, G.F., and Vouk, V. eds.) Elsevier Science Publishers B.V., Amsterdam.

    Google Scholar 

  27. Staal, F.J.T., M. Roeder, L.A. Herzenberg, and L.A. Herzenberg. 1990. Intracellular thiols regulate activation of nuclear factor kB and transcription of human immunodeficiency virus. Proc.Natl.Acad.Sci.U.SA.87: 9943–9947.

    Article  CAS  Google Scholar 

  28. Schreck, R., P. Rieber, and P.A. Baeuerle. 1991. Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kB transcription factor and HIV-1. EMBO J.2410: 2247–2258.

    Google Scholar 

  29. Meyer, M., W.H. Caselmann, V. Schlueter, R. Schreck, P.H. Hofschneider, and P.A. Baeuerle, 1992. Hepatitis B virus transactivator MHBst: activation of NF-kB, selective inhibtion by antioxidants and integral membrane localization. EMBO J. 11: 2991–3001.

    PubMed  CAS  Google Scholar 

  30. Standiford, T.J., Strieter, R.M., Chensue, S.W., Westwick, J., Kasahara, K., and Kunkel, S.L. 1990. IL-4 inhibits the expression of IL-8 from stimulated human monocytes. JImmunol. 145: 1435–1439.

    CAS  Google Scholar 

  31. Larsen C.G., M. Kristensen, K. Paludan, B. Deluran, M.K. Thomsen, C. Zachariae, Kragballe, K. Matsushima, and K. Thestrup-Pedersen. 1991. 1,25(OH)2-D3 is a potent regulator of interleukin-1 induced interleukin-8 expression and production. Biochem.Biophys.Res.Commun. 176: 1020–1026.

    Google Scholar 

  32. Jonat, C., H.J. Rahmsdorf, K.-K. Park, A.C.B. Cato, S. Gebel, H. Ponta, and P. Herrlich. 1990. Antitumor promotion and anti inflammation: down-modulation of AP-1 (fos/jun) activity by glucocorticoid hormone. Cell62: 1189–1204.

    Article  PubMed  CAS  Google Scholar 

  33. Yang-Yen, H.-F., J.-C. Chambard, Y.-L. Sun, T. Smeal, T.J. Schmidt, J. Drouin, and M. Karin. 1990. Transcriptional interference between c-jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction. Cell62: 1205–1215.

    Article  PubMed  CAS  Google Scholar 

  34. Schreiber, S.L. and G.R. Crabtree. 1992. The mechanism of action of cyclosporin A and FK506. Immunol.Today.13: 136–142.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departments of Pharmacology Cancer Research Institute, Kanazawa University, Kanazawa, 920, Japan

    Shu-ichi Okamoto, Naofumi Mukaida, Kazuo Yasumoto, Hyogo Horiguchi & Kouji Matsushima

  2. Departments of Surgery Cancer Research Institute, Kanazawa University, Kanazawa, 920, Japan

    Kazuo Yasumoto

  3. Department of Public Health Faculty of Medicine, Toyama Medical and Pharmaceutical University, Toyama, 930-01, Japan

    Hyogo Horiguchi

Authors
  1. Shu-ichi Okamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Naofumi Mukaida
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kazuo Yasumoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hyogo Horiguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kouji Matsushima
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Sandoz Research Institute, Vienna, Austria

    I. J. D. Lindley

  2. University of Bath, Bath, UK

    J. Westwick

  3. University of Michigan, Ann Arbor, Michigan, USA

    S. Kunkel

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer Science+Business Media New York

About this chapter

Cite this chapter

Okamoto, Si., Mukaida, N., Yasumoto, K., Horiguchi, H., Matsushima, K. (1993). Molecular Mechanism of Interleukin-8 Gene Expression. In: Lindley, I.J.D., Westwick, J., Kunkel, S. (eds) The Chemokines. Advances in Experimental Medicine and Biology, vol 351. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2952-1_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4615-2952-1_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6283-8

  • Online ISBN: 978-1-4615-2952-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation