Abstract
Many studies in recent years have been directed towards producing fully synthetic peptide immunogens (Francis and Clarke 1989; Francis 1993, this volume) which contain the necessary B- and T-cell epitopes for immunogenicity in vivo. However, there is little doubt that carrier proteins still offer the most straightforward and convenient way of presenting poorly immunogenic peptides to the immune system. This may be achieved either by chemical linkage of synthetic peptides to “foreign” protein molecules or by direct linkage to proteins for expression as recombinant fusion proteins. However it should be recognised that the method used to link the peptide to the carrier can greatly influence both the quantitative and qualitative nature of the immune response observed.
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Francis, M.J. (1993). Carriers for Peptides: Theories and Technology. In: Gregoriadis, G., McCormack, B., Allison, A.C., Poste, G. (eds) New Generation Vaccines. NATO ASI Series, vol 261. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2948-4_4
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DOI: https://doi.org/10.1007/978-1-4615-2948-4_4
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