Abstract
Inotropic alterations may alter contractile efficiency. Positive inotropic agents act mainly, if not exclusively, by increasing activation, which has very little effect on contractile efficiency. The metabolic effects of hypoxia may depress the contractile machinery directly. Acidosis is likely to decrease efficiency while an elevated phosphate, by itself, is likely to have little effect on efficiency.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Podolin RA, Ford LE. The influence of calcium on shortening velocity of skinned frog muscle fibres. J Muscle Res Cell Motility 1983; 4: 263–282.
Podolin RA, Ford LE. Influence of partial activation on the force velocity properties of frog skinned muscle fibres in millimolar magnesium ion. J Gen Physiol 1986; 87: 607–631.
Moss RL. Effects on shortening velocity of rabbit skeletal muscle due to variations in the level of thin-filament activation. J Physiol 1986; 377: 487–505.
Chiu CY, Ballou EW, Ford LE. Force, velocity, and power changes during normal and potentiated contractions of cat papillary muscle. Circ Res 1987; 60: 446–458.
Chiu CY, Walley KR, Ford LE. Comparison of the effects of different inotropic interventions on force, velocity, and power in rabbit myocardium. Circ Res 1989; 65: 1161–1171.
Winegrad S. Regulation of cardiac contractile proteins: correlations between physiology and biochemistry. Circ Res 1984; 55: 564–574.
Blinks JR, Endoh M. Modification of myofibrillar responsiveness to Ca++ as an inotropic mechanism. Circulation 1986; 60 (Suppl. III): 111–85–111–97.
Allen DG, Orchard CH. Measurement of intracellular calcium concentration in heart muscle; The effects of inotropic interventions and hypoxia. J Mo! Cell Cardiol 1987; 16: 117–128.
Berman MR, Peterson JN, Yue DT, Hunter WC. Effect of isoproterenol on force transient time course and on stiffness spectra in rabbit papillary muscle in barium contracture. J Mol Cell Cardiol 1988; 20: 415–426.
Hoh JFY, Rossmanith GH, Lee JK, Hamilton AM. Adrenaline increases the rate of cycling of crossbridges in rat cardiac muscle as measured by pseudo—random binary noise perturbation analysis. Circ Res 1988; 62: 452–461.
Brenner B, Schoenberg M, Chalovich JM, Greene LE, Eisenberg E. Evidence for cross—bridge attachment in relaxed muscle at low ionic strength. Prot Nat Acad Sci USA 1982; 79: 7288–7291.
Allen DG, Blinks JR. Calcium transients in aequorin—injected frog cardiac muscle. Nature 1978; 273: 509–513.
Seow CY, Ford LE. High ionic strength and low pH detain skinned rabbit skeletal muscle crossbridges in a low force state. 1993, (sumbitted).
Huxley AF, Simmons RM. Proposed mechanism of force generation in striated muscle. Nature 1971; 233: 533–538.
Ford LE, Huxley AF, Simmons RM. The relation between stiffness and filament overlap in stimulated frog muscle fibres. J Physiol 1981; 311: 219–249.
Seow CY, Ford LE. Shortening velocity and power output of skinned muscle fibers from mammals having a 25,000—fold range of body mass. J Gen Physiol 1991; 97:541–560.
Katz AM, Hecht HA. The early pump failure of the ischemic heart. Am J Med 1969; 47: 497–502.
Allen DG, Morris PG, Orchard CH, Pirolo JS. A nuclear magnetic resonance study of metabolism in the ferret heart during hypoxia and glycolysis. J Physiol 1985; 361: 185–204.
Seow CY, Ford LE. ADP detains muscle cross—bridges near the end of their force producing power stroke (abstract). Biophys J 1992; 61: A294
Bremel RD, Weber A. A cooperation within actin thin filament in vertebrate skeletal muscle. Nature New Biol 1972; 238: 97–101.
Seow CY, Ford LE. Dual effect of phosphate on the crossbridge cycle of muscle (abstract). Biophys J 1993; 63: (in press).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
Ford, L.E. (1993). Myocardial Energetics. In: Sideman, S., Beyar, R. (eds) Interactive Phenomena in the Cardiac System. Advances in Experimental Medicine and Biology, vol 346. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2946-0_5
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2946-0_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6280-7
Online ISBN: 978-1-4615-2946-0
eBook Packages: Springer Book Archive