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Intracellular Signaling in Vascular Smooth Muscle

  • Chapter
Interactive Phenomena in the Cardiac System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 346))

Abstract

The two major modalities of pharmacomechanical coupling, inositol 1,4,5 trisphosphate induced Ca2+ release and modulation of Ca2+-sensitivity, are reviewed. Recent studies show that although changes in cytoplasmic Ca2+ play the major role in regulating smooth muscle contraction, agonists can also significantly affect the contractile state by modifying Ca2+-sensitivity. Inhibition of myosin light chain kinase or myosin light chain phosphatase leads to, respectively, desensitization or sensitization of the contractile apparatus to Ca2+. G-protein linked inhibition of myosin light chain phosphatase and Ca2+ release mediated by the phosphatidylinol cascade are the two major pharmacomechanical coupling mechanisms.

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Authors and Affiliations

  1. Department of Pathology and Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, 22908, USA

    Avril V. Somlyo

  2. Department of Molecular Physiology and Biological Physics, and the Department of Medicine (Cardiology), University of Virginia, Charlottesville, VA, 22908, USA

    Andrew P. Somlyo

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  1. Avril V. Somlyo
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  2. Andrew P. Somlyo
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Editors and Affiliations

  1. Technion-Israel Institute of Technology, Haifa, Israel

    Samuel Sideman  & Rafael Beyar  & 

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© 1993 Springer Science+Business Media New York

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Somlyo, A.V., Somlyo, A.P. (1993). Intracellular Signaling in Vascular Smooth Muscle. In: Sideman, S., Beyar, R. (eds) Interactive Phenomena in the Cardiac System. Advances in Experimental Medicine and Biology, vol 346. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2946-0_4

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  • DOI: https://doi.org/10.1007/978-1-4615-2946-0_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6280-7

  • Online ISBN: 978-1-4615-2946-0

  • eBook Packages: Springer Book Archive

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