Abstract
In rat femoral arteries situated distally from a unilateral partial iliac artery obstruction, we observed: (i) 30% reduction of media cross sectional area, without alteration of arterial DNA content, (ii) a steeper relationship between strain and circumferential wall stress at rest, (iii) 12% reduction of the diameter at which maximal active wall tension was observed, (iv) reduction (25%) of maximal active wall tension, but not maximal active wall stress, and (v) a leftward shift of the relationship between diameter and sensitivity for contractile stimuli. Chronic flow reduction at constant pressure, did not modify arterial properties. These findings indicate that (pulse) pressure, influences arterial structure and function primarily by an effect on arterial smooth muscle cell volume. Vascular remodeling may thus result from disproportionate effects on vessel wall components.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Folkow B. Physiological aspects of primary hypertension. Physiol Rev 1982; 62: 347–504.
Cox RH. Mechanical properties of arteries in hypertension. In: Lee RMKW (eds), Blood Vessel Changes in Hypertension: Structure and Function. Boca Raton, FL: CRC Press, 1989, pp 65–98.
Mulvany MJ. Structure and function of small arteries in hypertension. J Hypertension 1990; 8:S225–S232.
Lever AF. Slow pressor mechanisms in hypertension: a role for hypertrophy of resistance vessels? J Hypertension 1986; 4: 515–524.
Bund SJ, West KP, Heagerty AM. Effects of protection from pressure on resistance artery morphology and reactivity in spontaneously hypertensive and Wistar-Kyoto rats. Circ Res 1991; 68: 1230–1240.
Lever A, Harrap SB. Essential hypertension: a disorder of growth with origins in childhood? J Hypertension 1992; 10: 101–120.
Folkow B, Gurevich M, Halfback M, Lundgren Y, Weiss L. The hemodynamic consequences of regional hypotension in spontaneously hypertensive and normotensive rats. Acta Physiol Scand 1971; 83: 532–541.
Tsoporis J, Fields N, Lee RMKW, Leenen FHH. Arterial vasodilation and cardiovascular structural changes in normotensive rats. Am J Physiol 1991; 260: H1944–H1952.
Struijker Boudier HAJ, Van Bortel LMAB, De Mey JGR. Remodeling of the vascular tree in hypertension: drug effects. TIPS 1990; 11: 240–245.
Hajdu MA, Heistad DD, Baumbach GL. Effects of antihypertensive therapy on mechanics of cerebral arterioles in rats. Hypertension 1991; 17: 308–316.
Tsoporis J, Leenen FHH. Effects of arterial vasodilators on cardiac hypertrophy and sympathetic activity in rats. Hypertension 1988; 11: 376–386.
Hajdu MA, Heistad DD, Ghonheim S, Baumbach GL. Effects of antihypertensive treatment on composition of cerebral arterioles. Hypertension 1991; 18 (suppl II): 1115–1121.
Labarca C, Paigen K. A simple, rapid and sensitive DNA assay procedure. Anal Biochem 1980; 102: 344–352.
Mulvany MJ, Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 1977; 41: 19–26.
Boonen HCM, De Mey JGR. Increased calcium sensitivity in isolated resistance arteries from spontaneously hypertensive rats: effects of dihydropyridines. Eur J Pharmacol 1990; 179: 403–412.
Freslon JL, Guidicelli JF. Vascular effects of captopril and dihydralazine in spontaneously hypertensive rats. Prog Appl Microcirc 1985; 8: 142–151.
Mulvany MJ, Warshaw DM. The active tension-length curve of vascular smooth muscle related to its cellular components. J Gen Physiol 1979; 74: 85–104.
Thorns R. Untersuchungen uber die histogenese and histomechanik des gefasssystems. Stuttgart: Verlag von Ferdinand Enke. 1893.
Glagov S, Vito R, Giddens DP, Zarins CK. Micro-architecture and composition of artery walls: relationship to location, diameter and the distribution of mechanical stress. J Hypertension 1992; 10 (suppl 6): S101–5104.
Owens GK. Control of hypertrophic versus hyperplastic growth of vascular smooth muscle cells. Am J Physiol 1989; 257: H1755–H1765.
Baunbach GL, Heistad DD. Remodeling of cerebral arterioles in chronic hypertension. Hypertension 1989; 13: 968–972.
Langille BL, O’Donnel F. Reductions in arterial diameter produced by chronic decreases in blood flow are endothelium dependent. Science 1986; 231: 405–407.
Aalkjaer C, Heagerty AM, Petersen KK, Swales JD, Mulvany MJ. Evidence for increased media thickness, increased neuronal uptake, and depressed excitation-contraction coupling in isolated resistance vessels from essential hypertensives. Circ Res 1987; 61: 181–186.
Heagerty AM, Aalkjaer C, Bund SJ. Effects of drug treatment on human resistance arteriole morphology in essential hypertension: direct evidence for structural remodelling of resistance vessels. Lancet 1988; 26: 1209–1212.
Johnson PC. The myogenic response. In: The Cardiovascular System, Vol II: Vascular Smooth Muscle. Bethesda, MD: Am Physiol Soc, 1980, pp 409–442.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer Science+Business Media New York
About this chapter
Cite this chapter
de Mey, J.G.R., Van Der Heijden, H., Janssen, G., Fazzi, G. (1993). Structural and Functional Remodeling of Poststenotic Arteries in the Rat. In: Sideman, S., Beyar, R. (eds) Interactive Phenomena in the Cardiac System. Advances in Experimental Medicine and Biology, vol 346. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2946-0_27
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2946-0_27
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4613-6280-7
Online ISBN: 978-1-4615-2946-0
eBook Packages: Springer Book Archive