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Regulation of Intracellular Calcium in Cardiac Muscle

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Interactive Phenomena in the Cardiac System

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 346))

Abstract

We have investigated the regulation of intracellular free calcium in heart muscle using the free acid form of the Ca2+ indicator fura-2 iontophoretically microinjected into rat cardiac trabeculae or ferret papillary muscles. This method shows great promise in elucidating a number of crucial questions in cardiac excitation-contraction coupling.

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References

  1. Backx PH, terKeurs, HEDJ. Fluorescent properties of rat cardiac trabeculae microinjected with fora-2 salt. Am J Physiol 1993; in press.

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  2. Li Q, Altschuld RA, Stokes BT. Quantitation of intracellular free calcium in single cardiomyocytes by fura-2 fluorescence microscopy. Biochem Biophys Res Commun 1987; 147:120–126.

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  3. Yue DT, Marban E, Wier WG. Relationship between force and intracellular [Ca2+] in tetanized mammalian heart muscle. J Gen Physiol 1986; 87:223–242.

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Author information

Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, The Johns Hopkins University, 844 Ross Building, Baltimore, MD, 21205, USA

    Eduardo Marban

Authors
  1. Peter H. Backx
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  2. Wei Dong Gao
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  3. Michelle D. Azan-Backx
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  4. Eduardo Marban
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Editor information

Editors and Affiliations

  1. Technion-Israel Institute of Technology, Haifa, Israel

    Samuel Sideman  & Rafael Beyar  & 

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© 1993 Springer Science+Business Media New York

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Backx, P.H., Gao, W.D., Azan-Backx, M.D., Marban, E. (1993). Regulation of Intracellular Calcium in Cardiac Muscle. In: Sideman, S., Beyar, R. (eds) Interactive Phenomena in the Cardiac System. Advances in Experimental Medicine and Biology, vol 346. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-2946-0_1

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  • DOI: https://doi.org/10.1007/978-1-4615-2946-0_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-6280-7

  • Online ISBN: 978-1-4615-2946-0

  • eBook Packages: Springer Book Archive

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