Abstract
Dendritic cells (DC) although a minor bone-marrow derived cell population, play an important role in initiating T-cell-mediated immune responses (Steiman and Inaba, 1989). The involvement of DC in acquired immune deficiency syndrome (AIDS) has been suggested by several reports (Eales et al.,1988; Patterson and Knight,1987; Langhoff et al.,1991). Patterson and Knight (1987), using a preparation containing 2 to 48% DC, detected viral budding from the plasma membrane 5 days after HIV-IIIB infection. Surprisingly, Langhoff et al (1991) reported that DC produced ∼ 10-fold more virus, than did T lymphocytes or fresh adherent monocyte populations when infected with several strains of HIV. Our studies were designed to test the relative ability of different strains of HIV-1 displaying different cellular tropism, to infect human peripheral blood DC and to determine the effect of such infection on DC accessory functions.
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© 1993 Plenum Press, New York
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Chehimi, J., Prakash, K., Shanmugam, V., Jackson, S.J., Bandyopadhyay, S., Starr, S.E. (1993). In-Vitro Infection of Peripheral Blood Dendritic Cells with Human Immunodeficiency Virus-1 Causes Impairment of Accessory Functions. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_87
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_87
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