Abstract
The system of dendritic cells (DC) comprises a diverse lineage, distributed throughout the tissues of the body, in different stages of development and maturation. DC develop from precursors in the bone marrow but it has proved difficult to isolate these cells in marrow culture. Recently, however, proliferating MHC class II-negative precursors, presumably in transit from the bone marrow to the tissues, have been isolated from mouse blood1. The dendritic leukocytes (DL) resident in the tissues are, by definition, MHC class II-positive, but it is uncertain whether in most tissues there is also a significant population of resident MHC class II-negative precursors. In the thymus2 and neonatal epidermis3, at least, MHC class II-negative precursors have been demonstrated. Langerhans cells (LC) which have the capacity to endocytose and process antigens, and probably other non-lymphoid DL, appear to be immature lymphoid DC that migrate to the lymphoid tissues, via the lymph (or blood), and there as mature DC initiate primary T-dependent responses.
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© 1993 Plenum Press, New York
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Roake, J.A., Rao, A.S., Larsen, C.P., Hankins, D.F., Morris, P.J., Austyn, J.M. (1993). Cytokine Mediators of Non-Lymphoid Dendritic Cell Migration. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_84
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_84
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