Abstract
It is the aim of this investigation to elucidate the cellular mechanisms responsible for graft acceptance in rat transplantation models after PUVA pretreatment of the graft. PUVA-therapy is used successfully in the treatment of psoriasis and other dermatoses with local accumulations of dendritic cells, as well as skin-lymphomas. Following these experiences Oesterwitz et al. (1989) developed a PUVA-treatment of the graft before transplantation. In this respect PUVA means: i. v. injection of the photoactive substance 8-Methoxypsoralen into the donor and in vitro exposure of the kidney graft to long wave UVA-irradiation. This PUVA therapy significantly prolonged graft survival times in rats even across a strong MHC-barrier. It has been shown, that 40% of PUVA treated rat kidneys are accepted by the recipient for more than 100 days. MHC-class-II-positive dendritic cells present donor specific alloantigen to the recipient and induce rejection. PUVA treatment reduces the expression of MHC-class-II-molecules and may lead to tolerance of the recipient towards the graft.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Hart, D. N. J., Winearls, C. G., and Fabre J. W., 1980, Graft adaptation: Studies on possible mechanisms in long-term surviving rat renal allografts, Transplantation 30: 73
Larsen, C. P., Morris P. J., and Austyn J. M., 1990, Migration of dendritic leukocytes from cardiac allografts into host spleens, J. Exp. Med. 171: 307.
Oesterwitz H., Kaden J., Gruner S., Schneider W., Eichler C., Schirrow R., May G., Scholz D., and Mebel M., 1989, PUVA-Behandlung von Organtransplantaten — experimentelle und klinische Ergebnisse, Z. Urol. Nephrol. 82: 1.
Perry M. E., Brown K. A., and Gaudecker von B., 1992, Ultrastructural identification and distribution of the adhesion molecules ICAM-1 and LFA-1 in the vascular and extravascular compartments of the human palatine tonsil, Cell Tissue Res 268: 317.
Tang A., and Udey M. C., 1991, Inhibition of epidermal Langerhans cell function by low dose ultraviolet B radiation. — Ultraviolet B radiation selectively modulates ICAM-1 (CD54) expression by murine Langerhans cells, J. Immunology 146, 3347.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Plenum Press, New York
About this chapter
Cite this chapter
Gaudecker, B.V., Petersen, R., Epstein, M., Kaden, J., Oesterwitz, H. (1993). Down-Regulation of MHC-Expression on Dendritic Cells in Rat Kidney Grafts by Puva Pretreatment. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_83
Download citation
DOI: https://doi.org/10.1007/978-1-4615-2930-9_83
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4613-6272-2
Online ISBN: 978-1-4615-2930-9
eBook Packages: Springer Book Archive