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Dendritic Cells in Fundamental and Clinical Immunology pp 469–480Cite as

Langerhans Cells as Outposts of the Dendritic Cell System

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 329))

Abstract

The T cell function associated dendritic cell (DC) system consists of various members located in different organs and differing in phenotypic expression, possibly on the basis of different states of “maturation” or as a direct result of microenvironmental influences. These DC, whether located in lymphoid or non-lymphoid tissues, are present only as a very minor cell population. In human blood, less than 0. 1% of the white blood cells are DC. 1 In the epidermis, Langerhans cells (LC) represent 3 to 5% of the total population. 2 In spleen cell suspensions, the DC are about 1–1. 6% of the cells. 3

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Authors and Affiliations

  1. Departments of Dermatology and Pathology and the Kaplan Cancer Center, New York University School of Medicine, New York, NY, 10016, USA

    A. H. Warfel, G. J. Thorbecke & D. V. Belsito

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  1. A. H. Warfel
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  2. G. J. Thorbecke
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  3. D. V. Belsito
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  1. Vrije Universiteit, Amsterdam, The Netherlands

    Eduard W. A. Kamperdijk  & Elisabeth C. M. Hoefsmit  & 

  2. University of Groningen, Groningen, The Netherlands

    Paul Nieuwenhuis

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Warfel, A.H., Thorbecke, G.J., Belsito, D.V. (1993). Langerhans Cells as Outposts of the Dendritic Cell System. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_79

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