Abstract
Common Variable Immunodeficiency (CVI) is a syndrome characterised by hypogammaglobulinaemia and defects in cellular immunity. 1 The differentiation of B-lymphocytes into plasma cells does not occur and the patients suffer from recurrent infections. 2 About 30% of CVI cases develop splenomegaly. 3 Some of these patients develop symptoms of hypersplenism which further increases their susceptibility to infection. 3 In most cases the mechanism is benign, but unknown. Splenectomy is often required to control hypersplenism and two such cases are presented here, together with a third patient whose spleen was removed for suspected lymphoma, which was not found. A spleen from a healthy donor was provided by a liver transplant team. Conventional histological and immunohistochemical techniques were used to study the distribution of macrophages, follicular dendritic cells (FDC) and B-lymphocytes. The principal finding was the presence of granulomas in all 3 CVI spleens.4
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© 1993 Plenum Press, New York
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Weston, J., Balfour, B.M., Tsohas, W., English, N., Farrant, J., Webster, A.D.B. (1993). Splenic Lesions in Hypogammaglobulinaemia. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_73
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_73
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