Dendritic Cells are Potent Antigen-Presenting Cells for Microbial Superantigen
Part of the
Advances in Experimental Medicine and Biology
book series (AEMB, volume 329)
Dendritic cells (DC) were found to be more efficient than macrophages (MO) in activating T cell responses to Staphylococcal enterotoxin B (SEB) using the hanging drop techniques and DC as antigen presenting cells (APC). When superantigen was presented via DC, the activation of T cells was not dependent on antigen processing and MHC class II molecules IA and IE were involved.
KeywordsDendritic Cell Major Histocompatibility Complex Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Staphylococcal Enterotoxin
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
M. P. Langford, G. J. Stanton and H. M. Johnson. Biological effects of Staphylococcal enterotoxin A on human peripheral lymphocytes. Infect. Immun.
22: 62 (1978).PubMedGoogle Scholar
B. Fleischer and H. Schrezenmeier. T cell stimulation by Staphylococcal enterotoxins. Clonally variable response and requirement for major histocompatibility complex class II molecules on accessory or target cells. J. exp. Med.
167: 1697 (1988).PubMedCrossRefGoogle Scholar
P. Dellabona, J. Pecoud, J. Kappler, P. Marrack, C. Benoist and D. Mathis. Superantigens interact with MHC class II molecules outside of the antigen groove. Cell
62: 1115 (1990).PubMedCrossRefGoogle Scholar
Y. Choi, B. Kotzin, L. Herron, J. Callahan, P. Marrack and J. Kappler. Interaction of Staphylococcus aureus toxin’ superantigens’ with human T cells. Proc. Natl. Acad. Sci. USA.
86: 8941 (1989).PubMedCrossRefGoogle Scholar
P. K. Legaard, R. D. Legrand and M. L. Misfeldt. The superantigen Pseudomonas exotoxin A requires additional functions from accessory cells for T lymphocyte proliferation. Cell. Immun.
135: 372 (1991).CrossRefGoogle Scholar
S. C. Knight. “Lymphocytes — A Practical Approach” G. G. B. Klaus, ed, IRL Press Ltd. Oxford (1987).Google Scholar
J. Yagi, J. Baron, S. Buxser and C. J. Janeway. Bacterial proteins that mediate the association of a defined subset of T cell receptor: CD4 complexes with class II MHC. J. Immunol.
144: 892 (1990).PubMedGoogle Scholar
N. Bhardwaj, S. M. Friedman, B. C. Cole and A. J. Nisanian. Dendritic cells are potent antigen-presenting cells for microbial superantigens. J. exp. Med.
175: 267 (1992).PubMedCrossRefGoogle Scholar
R. Inaba and R. M. Steinman. Resting and sensitized T lymphocytes exhibit distinct stimulatory (antigenpresenting cell) requirements for growth and lymphokine release. J. exp. Med.
160: 576 (1984).Google Scholar
S. E. Macatonia, S. Patterson and S. C. Knight. Primary proliferative and cytotoxic T-cell responses to HIV induce. in vitro
by human dendritic cells. Immunology
74: 399 (1991).PubMedGoogle Scholar
S. E. Macatonia, P. M. Taylor, S. C. Knight and B. A. Askonas. Primary stimulation by dendritic cells induces antiviral proliferative and cytotoxic T cell response. in vitro
. J. Exp. Med.
169: 1255 (1989).PubMedCrossRefGoogle Scholar
W. E. F. Klinkert, J. H. Labadie and W. E. Bowers. Accessory and stimulating properties of dendritic cells and macrophages isolated from various rat tissues. J. exp. Med.
156: 1 (1982).PubMedCrossRefGoogle Scholar
J. Yagi, S. Rath and C. A. Janeway Jr. Control of T cell responses to Staphylococcal enterotoxins by stimulator cell MHC class II polymorphism. J. Immunol.
147: 1398 (1991).PubMedGoogle Scholar
J. D. Fraser. High affinity binding of Staphylococcal enterotoxins A and B to HLA-DR. Nature
339: 221 (1989).PubMedCrossRefGoogle Scholar
© Springer Science+Business Media New York 1993