Dendritic Cells are Potent Antigen-Presenting Cells for Microbial Superantigen

  • Sharifah Iqball
  • Penelope Bedford
  • Stella Knight
  • Reshma Bhatt
  • Peter Borriello
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)


Dendritic cells (DC) were found to be more efficient than macrophages (MO) in activating T cell responses to Staphylococcal enterotoxin B (SEB) using the hanging drop techniques and DC as antigen presenting cells (APC). When superantigen was presented via DC, the activation of T cells was not dependent on antigen processing and MHC class II molecules IA and IE were involved.


Dendritic Cell Major Histocompatibility Complex Major Histocompatibility Complex Class Major Histocompatibility Complex Molecule Staphylococcal Enterotoxin 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Sharifah Iqball
    • 1
  • Penelope Bedford
    • 1
  • Stella Knight
    • 1
  • Reshma Bhatt
    • 2
  • Peter Borriello
    • 2
  1. 1.Antigen Presentation Research GroupClinical Research CentreHarrow MiddlesexUK
  2. 2.Microbial Pathogenicity ResearchClinical Research CentreHarrow MiddlesexUK

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