Abstract
Follicular dendritic cells (FDCs) degenerate in individuals manifesting persistent generalized lymphadenopathy after infection with HIV. At the light microscopic level, this degeneration of FDC is noted by the destruction of the FDC network in lymph node follicles1-3, and it is called “follicle lysis”1. Ultimately, FDC are depleted as indicated by a lack of labeling with FDC specific monoclonal antibodies3. At the electronmicroscopic level, it has been reported that HIV, observed as viral particles, were attached to the processes of FDC2,4. These findings support the concept that HIV infection leads to destruction of FDC and loss of FDC functions.
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© 1993 Plenum Press, New York
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Masuda, A., Burton, G.F., Fuchs, B.A., Szakal, A.K., Tew, J.G. (1993). Destruction of Follicular Dendritic Cells in Murine Acquired Immunodeficiency Syndrome (Maids). In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_69
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_69
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