Abstract
In the first phase of infection by the Human Immunodeficiency Virus type 1 (HIV-1), persistent generalised lymphadenopathy can be the only feature of the disease, with or without associated clinical symptoms. The main histologic abnormality observed in the swollen lymph node is hyperplasia of follicles. The network comprising of follicular dendritic cells (FDC) appears to be damaged. Immunohistochemistry shows signs of fragmentations and indentations. HIV-1 components have been suggested to play a role in this process, as proteins, 1,2 virions3 and mRNA2,4 of the virus are concentrated in the germinal centers. We5 and others6 have provided evidence that FDC can be infected by HIV-1. Some authors have proposed a role for the immune response towards the virus. This was supported by the demonstration of cytotoxic cells, documented by the presence of mRNA encoding serine esterase Granzyme B, which occurs in granules of cytotoxic cells.7
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© 1993 Plenum Press, New York
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Joling, P. et al. (1993). Lymphoid Follicles in Cynomolgus Monkeys after Infection with Simian Immunodeficiency Virus. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_68
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_68
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