Abstract
Follicular dendritic cells (FDC) are located in B cell follicles and germinal centers (GC) of secondary lymphoid tissue (Szakal and Hanna, 1968; Nossal et al., 1968). Antigen retention in the form of immune complexes is one of the main properties of FDC (Szakal et al., 1989; Tew et al, 1990). The dendrites of several FDC intertwine to form a three-dimensional network called the antigen-retaining or FDC-reticulum (Szakal et al, 1989). Accumulating evidence indicates that FDC and the retained antigen are important in the production of B-memory cells and the long-term maintenance of secondary antibody response (Tew et al., 1990).
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© 1993 Plenum Press, New York
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Kapasi, Z.F., Szakal, A.K., Burton, G.F., Tew, J.G., Shultz, L.D. (1993). Cellular Requirements for Functional Reconstitution of Follicular Dendritic Cells in Scid Mice. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_64
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_64
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