A Dendritic Cell Specific Determinant Present In Endosomes Is Involved in the Presentation of Protein Antigens
Antigen presenting cells (APC) such as dendritic cells (DC), macrophages (M), and B lymphocytes present exogenous antigens on their cell surface to T cells, not as native proteins but as peptides, complexed with MHC-class II molecules (1). In contrast to macrophages where antigen processing occurs in endosomes (2). It is still unclear how and by which organelles the processing takes place in DC or B-cells (3). Using fluorescein conjugated protein antigen it has been shown that isolated splenic DC can take up some amount of protein antigen in intra-cytoplasmic organelles after over-night culturing. Furthermore, these DC were now able to prime T cells in situ (4). Therefore DC must have a small but relevant intra-cytoplasmic system for antigen processing.
KeywordsDendritic Cell Antigen Present Cell Protein Antigen Antigen Processing Invariant Chain
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