Abstract
Follicular dendritic cells (FDC) are specialized cells which locate within the lymphoid follicles of secondary lymphoid tissues including lymph nodes, spleen, tonsil and mucosal associate lymphoid tissues (Peyet’s patches etc). Many studies1,2,3 have been accumulated to defined the morphological, immuno-phenotypical and functional features of FDC. Nevertheless, the nature of FDC is still unsettled, especially the cellular origin, kinetics, proliferating activity, maturation processes and functional diversity. In this paper, we focused on the two major subjects, the heterogeneity and cellular origin of FDC because these are thought to be most fundamental for FDC research and summarize our recent results.
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References
Y. Imai, K. Terashima, M. Matsuda, M. Dobashi, K. Maeda and T. Kasajima, Reticulum cell and dendritic reticulum cell-Origin and function-Recent Adv. RES Res. 21: 51 (1983)
Y. Imai, M. Yamakawa, A. Masuda, T. Sato, and T. Kasajima, Function of the follicular dendritic cell in the germinal center of lymphoid follicles. Histol. Histopath. 1: 341 (1986)
J. Tew, M.H. Kosco, G.F. Burton and A.K. Szakal, Follicular dendritic cells as accessory cells. Immunological Rev. 117: 185 (1990)
M. Yamakawa and Y. Imai Complement activation in the follicular light zone of human lymphoid tissues. Immunology in press (1992)
L. H. P. M. Rademakers, H.-J. Schuurman, J.F. de Frankrijker and A. Van Ooyen Cellular composition of germinal centers in lymph nodes after HIV-1 infection: Evidence for an inadequate support of germinal center B lymphocytes by follicular dendritic cells. Clin. Immunol. Immunopathol. 62: 148 (1992)
K. Maeda, M. Matsuda and Y. Imai. Postnatal development of the immune complex retaining cells in the rat lymph nodes.-An immunofluorescent and electron microscopic study-. in preparation (1992)
K. Maeda, M. Matsuda and Y. Imai Postnatal development of murine follicular dendritic cells.-An immunoelectron microscopic study-. in preparation (1992)
K. Maeda, G.F. Burton, D.A. Padgett, D.H. Conrad, T.F. Huff, A. Masuda, A.K. Szakal and J.G. Tew Murine follicular dendritic cells and loe affinity Fc receptors for IeE (FceRII). J. Immunol. 148: 2340 (1992)
K. Maeda, M. Matsuda, R. Nagashima, N. Degawa and Y. Imai Follicular dendritic cells in malignant lymphomas-Distribution, phenotypes & ultrastructures-. in this proceedings (1992)
A. Cerny, R.M. Zinkernagel and P. Groscurth Development of follicular dendritic cells in lymph nodes of B-cell-depleted mice. Cell Tissue Res. 254: 449 (1988)
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© 1993 Plenum Press, New York
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Imai, Y. et al. (1993). Heterogeneity and Cellular Origin of Follicular Dendritic Cells. In: Kamperdijk, E.W.A., Nieuwenhuis, P., Hoefsmit, E.C.M. (eds) Dendritic Cells in Fundamental and Clinical Immunology. Advances in Experimental Medicine and Biology, vol 329. Springer, New York, NY. https://doi.org/10.1007/978-1-4615-2930-9_57
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DOI: https://doi.org/10.1007/978-1-4615-2930-9_57
Publisher Name: Springer, New York, NY
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