Serum-Free Differentiation of Rat and Human Dendritic Cells, Accompanied by Acquisition of the Nuclear Lamins A/C as Differentiation Markers

  • Robert K. H. Gieseler
  • Hui Xu
  • J. Hinrich Peters
  • Rolf Schlemminger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)


It is generally accepted that tissue macrophages (Mφ) derive from a common bone marrow (BM) precursor. Clearly, it is the myeloid lineage that branches into the development of Mφ and granulocytes. For contrast, the exact origin of organ-specific dendritic cells (DC) is still doubtful. In vitro studies may help to solve this controversy. In this report we therefore present results gained from such investigations in our laboratory.


Dendritic Cell Accessory Cell Nuclear Lamins Myeloid Lineage Human Dendritic Cell 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Robert K. H. Gieseler
    • 1
  • Hui Xu
    • 1
  • J. Hinrich Peters
    • 1
  • Rolf Schlemminger
    • 2
  1. 1.Department of ImmunologyUniversity of GöttingenGöttingenGermany
  2. 2.Department of General SurgeryUniversity of GöttingenGöttingenGermany

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