Monocyte-Derived Langerhans Cells from Different Species - Morphological and Functional Characterization
It has been demonstrated earlier that peripheral blood monocytes can be differentiated into antigen presenting accessory cellse.g.1,2, and also that mouse blood contains precursors of dendritic cells3. In the human system we have recently demonstrated the in-vitro differentiation of a Langerhans cells phenotype from peripheral blood monocytes for the first time, 4 indicating the possibility to study the suggested pathway from monocytes via Langerhans cells (LC) to dendritic cells (DC)5 in-vitro.
KeywordsDendritic Cell Peripheral Blood Monocyte Accessory Cell Mixed Lymphocyte Reaction Autologous Serum
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- 2.G. Rossi, N. Heveker, B. Thiele and H. Gelderblom, Mannan antigen presentation by monocyte-derived dendritic cells, in: Progress in AIDS research in the Fed. Rep. of Germany M. Schauzu, ed., MMV Medizin Verlag München (1990)Google Scholar
- 6.F. Steinbach and B. Thiele, Phenotypical investigation of mononuclear phagocytes by FACS analysis, in: N.N., P. Poidron, D. Wachsman eds., Intercept, Andover, G.B.(in press)Google Scholar
- 7.M. Ormerod, Analysis of DNA, in: Flow Cytometry, M. Ormerod ed., IRL Press, Oxford (1990)Google Scholar