Dissection of Human Langerhans Cell Allostimulatory Function. Modulation by Interferon-γ.
It has now become evident that dendritic cells (DC) are specialyzed in initiating primary T cell-dependent immune responses1. A particular large pool of DC, namely Langerhans cells (LC) are present within epidermis where they are the only cells which express MHC class II antigens constitutively. LC play a key role in the initiation of T cell responses to cutaneous antigens by picking up the antigen and migrating to the draining lymph nodes where they trigger specific T cell activation.
KeywordsDendritic Cell Accessory Function Genzyme Corporation Allostimulatory Activity Mononuclear Cell Suspension
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