IL-6 and Its High Affinity Receptor During Differentiation of Monocytes into Langerhans Cells
In the skin variable concentrations of IL-6 are a result of local production by Langerhans cells (LC), keratinocytes and endothelial cells (1), as well as of posthepatic accumulation (2). Although LC precursors leaving the capillaries must migrate through the dermis, it remains unclear how far IL-6 influences the development and function of LC.
KeywordsConditioned Medium High Affinity Receptor CD1a Expression Unbind Ligand Scatchard Plot Analysis
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- 1.Detmar, M., Hettmannsperger, U., Owsianowski, M. et al. (1991) Int. Archives Dermatol. 96, Abstracts, 999Google Scholar