The MHC Expression of Dendritic Cells from Mouse Spleen Isolated by Centrifugal Elutriation is Upregulated During Short Term Culture
Dendritic cells (DC) are extremely potent antigen presenting cells (APC), which can even induce an anti-viral specific primary T cell response in vitro (Macatonia et al, 1989). Both the quantitatively and qualitatively (fewer sialic acids) superior MHC expression and the large surface area of DC with long dendritic projections possibly allow a better interaction of the MHC-peptide complex on the DC with the T cell receptor (Boog et al., 1989). Generally, fewer DC than other types of APC are required to induce a specific T cell response (Kast et al., 1988).
KeywordsDendritic Cell Sialic Acid Glass Petri Dish Short Term Culture Centrifugal Elutriation
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