Advertisement

Three Monoclonal Antibodies to Antigen Presenting Cells in the Rat with Differential Influence on Cellular Interactions

  • Jan Damoiseaux
  • Ed Döpp
  • Marina Verdaasdonk
  • Ed Kamperdijk
  • Christine Dijkstra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)

Abstract

A physical interaction between antigen presenting cells (APC) and T cells is essential for evoking an immune response1. It has been proposed that T cells first bind to APC by an antigen-independent mechanism. Antigen specific lymphocytes are then selected and activated within the APC-T cell cluster resulting in T cell proliferation2. In the first stage several accessory molecules, like LFA-1, ICAM-1, CD2, and LFA-3, are involved in the antigen-independent interaction1,2,3. Thereafter the antigen-dependent interaction, mediated by the T cell receptor (TCR), CD3, CD4, and the MHC Class II molecule, becomes more important and induces cytokine production triggering T cell proliferation1,3,4,5. In the third stage, which can occur in the absence of APC, IL-2 alone mediates proliferation of the responsive T cells.

Keywords

Dendritic Cell Accessory Molecule Mixed Leukocyte Reaction Antigen Specific Lymphocyte Tritiated Thymidine Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P. D. King and D. R. Katz. Mechanisms of dendritic cell function. Immunol Today 11: 206 (1990).PubMedCrossRefGoogle Scholar
  2. 2.
    K. Inaba and R. M. Steinman. Accessory cell-T lymphocyte interactions. Antigen-dependent and independent clustering. J. Exp. Med. 163: 247 (1986).PubMedCrossRefGoogle Scholar
  3. 3.
    J. M. Austyn and P. J. Morris. T-cell activation by dendritic cells: CD18-dependent clustering is not sufficient for mitogenesis. Immunology 63: 537 (1988).PubMedGoogle Scholar
  4. 4.
    J. Green and R. Jotte. Interactions between T helper cells and dendritic cells during the rat mixed lymphocyte reaction. J. Exp. Med. 162: 1546 (1985).PubMedCrossRefGoogle Scholar
  5. 5.
    K. Inaba and R. M. Steinman. Monoclonal antibodies to LFA-1 and to CD4 inhibit the mixed leukocyte reaction after the antigen-dependent clustering of dendritic cells and T lymphocytes. J. Exp. Med. 165: 1403 (1987).PubMedCrossRefGoogle Scholar
  6. 6.
    J. M. Austyn, R. M. Steinman, D. E. Weinstein, A. Granelli-Piperno and M. A. Palladino. Dendritic cells initiate a two-stage mechanism for T lymphocyte proliferation. J. Exp. Med. 157: 1101 (1983).PubMedCrossRefGoogle Scholar
  7. 7.
    J. G. M. C. Damoiseaux, E. A. Döpp, J. J. Neefjes, R. H. J. Beelen and C.D. Dijkstra. Heterogeneity of macrophages in the rat evidenced by variability in determinants: two new anti-rat macrophage antibodies against a heterodimer of 160 and 95 kd (CD11/CD18). J. Leukocyte Biol. 46: 556 (1989).PubMedGoogle Scholar
  8. 8.
    A. P. Robinson, T. M. White and D. W. Mason. Macrophage heterogeneity in the rat as delineated by two monoclonal antibodies MRC OX-41 and MRC OX-42, the latter recognizing complement receptor type 3. Immunology 57: 239 (1986).PubMedGoogle Scholar
  9. 9.
    J. G. M. C. Damoiseaux. Macrophage Heterogeneity in the rat. PhD thesis, Vrije Universiteit Amsterdam (1991).Google Scholar
  10. 10.
    E. W. A. Kamperdijk, M. A. M. Verdaasdonk and R. H. J. Beelen. Visual and functional expression of Ia-antigen on macrophages and dendritic cells in ACI/Ma1 rats. Transplant. Proc. 19: 3024 (1987).Google Scholar
  11. 11.
    M. A. Schon-Hegrad, J. Oliver, P. G. McMenamin and P. G. Holt. Studies on the density, distribution, and surface phenotype of intraepithelial class II major histocompatability complex antigen (Ia)-bearing dendritic cells (DC) in the conducting airways. J. Exp. Med. 173: 1345 (1991).PubMedCrossRefGoogle Scholar
  12. 12.
    F. Sanchez-Madrid, J. A. Nagy, E. Robbins, P. Simon and T. A. Springer. A human leukocyte differentiation antigen family with distinct α-subunits and a common β-cubunit. J. Exp. Med. 158: 1785 (1983).PubMedCrossRefGoogle Scholar
  13. 13.
    P. A. Detmers and S. D. Wright. Adhesion-promoting receptors on leukocytes. Curr. Opin. Immunol. 1: 10 (1988).PubMedCrossRefGoogle Scholar
  14. 14.
    H. Rosen and S. Gordon. Monoclonal antibody to the murine type 3 complement receptor inhibits adhesion of myelomonocytic cells in vitro an inflammatory cell recruitment in vivo. J. Exp. Med. 166: 1685 (1987).PubMedCrossRefGoogle Scholar
  15. 15.
    S. El Rouby, F. Praz, L. Halbwachts-Mecarelli and M. Papiernik. Thymic reticulum in mice IV. The rosette formation between phagocytic cells of the thymic reticulum and cortical type thymocytes is mediated by complement receptor type three. J. Immunol. 134: 3625 (1985).PubMedGoogle Scholar
  16. 16.
    C. J. M. Melief. Dendritic cells as specialized antigen-presenting cells. Res. Immunol. 140: 902 (1989).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jan Damoiseaux
    • 1
  • Ed Döpp
    • 1
  • Marina Verdaasdonk
    • 1
  • Ed Kamperdijk
    • 1
  • Christine Dijkstra
    • 1
  1. 1.Department of Cell Biology Medical FacultyVrije UniversiteitAmsterdamThe Netherlands

Personalised recommendations