Three Monoclonal Antibodies to Antigen Presenting Cells in the Rat with Differential Influence on Cellular Interactions

  • Jan Damoiseaux
  • Ed Döpp
  • Marina Verdaasdonk
  • Ed Kamperdijk
  • Christine Dijkstra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)


A physical interaction between antigen presenting cells (APC) and T cells is essential for evoking an immune response1. It has been proposed that T cells first bind to APC by an antigen-independent mechanism. Antigen specific lymphocytes are then selected and activated within the APC-T cell cluster resulting in T cell proliferation2. In the first stage several accessory molecules, like LFA-1, ICAM-1, CD2, and LFA-3, are involved in the antigen-independent interaction1,2,3. Thereafter the antigen-dependent interaction, mediated by the T cell receptor (TCR), CD3, CD4, and the MHC Class II molecule, becomes more important and induces cytokine production triggering T cell proliferation1,3,4,5. In the third stage, which can occur in the absence of APC, IL-2 alone mediates proliferation of the responsive T cells.


Dendritic Cell Accessory Molecule Mixed Leukocyte Reaction Antigen Specific Lymphocyte Tritiated Thymidine Uptake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Jan Damoiseaux
    • 1
  • Ed Döpp
    • 1
  • Marina Verdaasdonk
    • 1
  • Ed Kamperdijk
    • 1
  • Christine Dijkstra
    • 1
  1. 1.Department of Cell Biology Medical FacultyVrije UniversiteitAmsterdamThe Netherlands

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