T-Cell Repertoire Development in MHC Class II Deficient Humans
We have investigated the impact of MHC class II deficiency on the development of the peripheral T-cell repertoire. During T-cell development, interactions between T-cell receptor (TcR) and MHC class I and class II molecules play a pivotal role in the positive and negative selection events that occur within the thymic micro-environment1,2, 3, 4,5. These MHC dependent selection processes influence in greater part the composition of the peripheral T-cell compartment, where only T-cells with moderate affinity for “self” MHC class I or class II molecules can be found6. Various studies in the mouse have shown that interference in these TcR/MHC interactions has a dramatic effect on the composition of the peripheral T-cell compartment with respect to development of T-cells co-expressing the accessory molecules CD4 or CD8 respectively.7,8,9,10
KeywordsGene Segment Segment Usage Deficient Environment Deficient Human Bare Lymphocyte Syndrome
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