Antigen Presenting Capacity of Peritoneal Macrophages and Dendritic Cells

  • Ellen van Vugt
  • Marina A. M. Verdaasdonk
  • Eduard W. A. Kamperdijk
  • Robert H. J. Beelen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)


Dendritic cells (DC) are very potent antigen presenting cells (1), that can be isolated from many lymphoid and non-lymphoid tissues from different species (2). Recently, we have demonstrated that in the peritoneal cavity of rats approximately 1 % of the cells are DC, based on similar morphological and functional characteristics as DC isolated from lymphoid organs (3). Next to this small number of DC, a large number of Mϕ (macrophages) is present in the peritoneal cavity, which are also capable of presenting antigen although to a lesser extent. Both cell types are bone marrow derived (4), but there are numerous morphological and functional differences (5) that suggest the existence of different cell lineages.


Dendritic Cell Peritoneal Cavity Peritoneal Lavage Peritoneal Cell Potent Antigen Present Cell 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Ellen van Vugt
    • 1
  • Marina A. M. Verdaasdonk
    • 1
  • Eduard W. A. Kamperdijk
    • 1
  • Robert H. J. Beelen
    • 1
  1. 1.Department of Cell Biology Division of Electron Microscopy Medical FacultyVrije UniversiteitBT AmsterdamThe Netherlands

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