The Influence of Dendritic Cells on T-Cell Cytokine Production
Pretreatment of mice with picryl chloride via the oral mucosa leads to a T-cell mediated tolerance after sensitization, while mice that do not receive this treatment react with a contact sensitivity (CS) response after topical skin application of picryl chloride(1). It is assumed that both in the oral epithelium and in the skin dendritic Langerhans cells are involved in the uptake of the antigen and subsequent transportation into the draining lymph nodes. Here the Langerhans cells will present antigen to T-cells in the para-cortical areas as interdigitating, dendritic cells.
KeywordsDendritic Cell Oral Mucosa Drain Lymph Node ELISPOT Assay Oral Tolerance
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