The Role Of Dendritic Cells in the Regulation of T Cell Cytokine Synthesis

  • Joanna Ellis
  • Mohammed A. A. Ibrahim
  • Benjamin M. Chain
  • David R. Katz
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)


Antigen presenting cells (APC) have been implicated frequently in the numerous cytokine network models, chiefly as a hypothetical source of a critical mediator that is important in induction of an immune response. The example usually quoted is interleukin 1 (IL-1) (1), even though it has been clear for some time that the most potent form of APC, the dendritic cell (DC), is an IL-1 responder rather than producer (2). Other cytokines, such as IL-6, have also been proposed as important in induction (3); but IL-6 effects are so pleiotropic that it is difficult to ascribe a specific APC related role to this cytokine (4).


Dendritic Cell Major Histocompatibility Complex Antigen Present Cell CTLL Cell Imperial Cancer Research Fund 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Joanna Ellis
    • 1
  • Mohammed A. A. Ibrahim
    • 1
  • Benjamin M. Chain
    • 1
  • David R. Katz
    • 1
  1. 1.Departments of HistopathologyImmunology and Biology University College LondonLondonUK

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