The Role Of Dendritic Cells in the Regulation of T Cell Cytokine Synthesis
Antigen presenting cells (APC) have been implicated frequently in the numerous cytokine network models, chiefly as a hypothetical source of a critical mediator that is important in induction of an immune response. The example usually quoted is interleukin 1 (IL-1) (1), even though it has been clear for some time that the most potent form of APC, the dendritic cell (DC), is an IL-1 responder rather than producer (2). Other cytokines, such as IL-6, have also been proposed as important in induction (3); but IL-6 effects are so pleiotropic that it is difficult to ascribe a specific APC related role to this cytokine (4).
KeywordsDendritic Cell Major Histocompatibility Complex Antigen Present Cell CTLL Cell Imperial Cancer Research Fund
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- 3.Holsti M. A. and Raulet D. H. J. Immunol. 143: 2514.Google Scholar