Distinct T Cell Stimulation Mechanism and Phenotype of Human Blood Dendritic Cells

  • Hui Xu
  • Ulrike Friedrichs
  • Robert K. H. Gieseler
  • Jörg Ruppert
  • J. Hinrich Peters
  • Göran Ocklind
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)


Dendritic cells (DC) have been found to exist as antigen-presenting cells in nonlymphoid and lymphoid tissues. 1,2 They play an important role in modulation of the immune reaction. 3,4 Blood dendritic cells (BDC), like other types of DC, exhibit distinct cellular characteristics and a strong potency to stimulate lymphocyte proliferation. 5, 6 Cell interaction via adhesion molecules has been demonstrated to function as a co-stimulatory signal in the T cell stimulation. 7,8 The blockage of adhesion molecules or their ligands by antibodies could reduce cell interaction and function.9,10


Dendritic Cell Costimulatory Signal Blood Dendritic Cell Peripheral Blood Dendritic Cell CD18 CD45 CD54 CD58 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Hui Xu
    • 1
  • Ulrike Friedrichs
    • 1
  • Robert K. H. Gieseler
    • 1
  • Jörg Ruppert
    • 1
  • J. Hinrich Peters
    • 1
  • Göran Ocklind
    • 2
  1. 1.Department of ImmunologyUniversity of GoettingenGoettingenGermany
  2. 2.Zoophysiological InstituteUniversity of UppsalaUppsalaSweden

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