Costimulating Factors and Signals Relevant for Antigen Presenting Cell Function
The antigen-specific activation of CD4+ T lymphocytes is absolutely dependent on ligands expressed on the surface of specialized hematopoietic cells1 known as antigenpresenting cells (APC). Recent results from many laboratories suggest that these ligands include: major histocompatibility complex (MHC) -encoded class II molecules that are important for presenting antigenic peptides to the T cell antigen receptor (TCR); adhesion molecules that facilitate the formation of T cell/APC conjugates; and molecules that transduce nonspecific costimulatory signals upon binding their complementary T cell receptors1-3. The efficiency of various APC types in their capacity to stimulate T cells can therefore be influenced by qualitative and/or quantitative differences in the expression or function of any of these molecules. Here we describe our analysis of the contribution of antigen-presentation, adhesion, and costimulation to the functional APC potency of dendritic cells and B cells.
KeywordsDendritic Cell Major Histocompatibility Complex Inositol Phosphate Major Histocompatibility Complex Molecule Costimulatory Signal
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