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Analysis of Cytokine and Cytokine Receptor Production by Human Dendritic Cells

  • Victoria L. Calder
  • Timothy C. R. Prickett
  • Judith L. McKenzie
  • Derek N. J. Hart
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)

Abstract

Dendritic cells (DC) have a unique ability to stimulate a primary T lymphocyte response. The presence of adhesion molecules on DC1 promotes the association of DC with T lymphocytes and the MHC antigen-peptide complex on DC triggers the responding T lymphocyte TCR (signal I). It is clear that additional cellular properties of the DC (signal II), as well as signalling via the adhesion molecules, are crucial to its function as a specialist antigen presenting cell (APC). 2 The nature of the DC co-stimulatory signal II remains unexplained but the possibility that DC produce cytokines such as IL-13 or IL-6, 4 which activate T lymphocytes, has been suggested. Convincing evidence that DC produce cytokines has not been forthcoming5,6 but it is clear that exogenous cytokines such as IL-17 and GM-CSF8 do impact on DC. These effects may be considered as a third signal involved in T cell activation (regulated by CD45) which primes DC to maximise their APC function.9

Keywords

Human Dendritic Cell Human Tonsil Blood Dendritic Cell Antigen Present Cell Function Beta mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Victoria L. Calder
    • 1
  • Timothy C. R. Prickett
    • 1
  • Judith L. McKenzie
    • 1
  • Derek N. J. Hart
    • 1
  1. 1.Haematology DepartmentChristchurch HospitalChristchurchNew Zealand

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