The Effect of Human Dendritic Cells on the Lectin-Induced Responsiveness of CD4+ T Cells To IL-2 and IL-4

  • Sergiusz Markowicz
  • Anita Mehta
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 329)


Human peripheral blood dendritic cells (DC) are potent accessory cells (AC) for the lectin-induced proliferative response of T lymphocytes1. However, the contribution of DC to the responsiveness of lectin-induced T cells to IL-2 and IL-4 is not clearly understood. The AC-dependent induction of IL-2 responsiveness by mitogenic lectin has been reported2. It has been also shown that the proliferation of lectin-induced T cells is promoted bv IL-2 or IL-4 in the absence of AC.3


Accessory Cell Human Dendritic Cell Memory Subset Autologous Mixed Lymphocyte Reaction Mitogenic Lectin 
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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Sergiusz Markowicz
    • 1
  • Anita Mehta
    • 2
  1. 1.Department of ImmunologyThe Maria Sklodowska-Curie Memorial Cancer Center and Institute of OncologyWarsawPoland
  2. 2.Department of PathologyStanford University School of MedicineStanfordUSA

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